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Will you gain weight back after stopping Ozempic?

Recent research published in the journal Diabetes, Obesity and Metabolism indicates that once patients stop using semaglutide drugs like Wegovy and Ozempic any weight they've lost is likely to return. According to Dr.

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Share on Pinterest Taking semaglutide medication like Wegovy and Ozempic can help people lose weight, but they often regain lost pounds once they stop. Sergey Mironov/Getty Images Research has found that when people stop using semaglutide, weight rebound occurs. Experts say this is because the drug is not a cure and it does not prevent the metabolic adaptation that occurs during weight loss. Long-term changes in diet and activity are an important part of maintaining weight loss. It is also important to consult with a physician before using weight loss medications. Recent research published in the journal Diabetes, Obesity and Metabolism indicates that once patients stop using semaglutide drugs like Wegovy and Ozempic any weight they’ve lost is likely to return. According to Dr. Ibiye Owei, Assistant Professor at Texas Tech University Health Sciences Center El Paso, semaglutide is a glucagon-like-peptide-1 agonist (GLP-1 agonist) which has been approved by the Food and Drug Administration (FDA) to treat diabetes and obesity or overweight. “It works by making people feel full sooner and suppressing the appetite so people do not feel as hungry,” she explained. “One of the ways it does this is by slowing emptying of the stomach so there is a feeling of satiety.” Owei added that anyone with obesity defined as a Body Mass Index (BMI) of 30 and above or a BMI of 27 and above who is experiencing weight-related complications such as hypertension or type 2 diabetes would be a good candidate to use this medication. Semaglutide is one of the most effective treatments for obesity According to Dr. Kathleen Dungan, an endocrinologist in the Division of Endocrinology, Diabetes & Metabolism at The Ohio State University Wexner Medical Center, there are several potential benefits to using semaglutide. “It is one of the most effective treatments available for either condition, outside of bariatric surgery,” said Dungan. “Moreover, there is evidence that the use of semaglutide may reduce the risk for developing diabetes and may be particularly useful in individuals who have prediabetes.” What happens when you quit taking semaglutide While drugs like Wegovy and Ozempic might seem like a miracle to those with diabetes and obesity, the truth is the effects only last while you are taking the medication. A study published in April 2022 which sought to examine changes in body weight and cardiometabolic risk factors upon the termination of the drug, found that after a year people had regained two-thirds of the weight they had lost. The positive changes they had seen in cardiometabolic risk factors like blood pressure, blood lipids, HbA1c, and C-reactive protein had similarly reversed. According to the study authors, these findings reinforce the need to continue treatment in order to maintain the benefits of the medication. Why rebound weight gain occurs According to Dungan, weight rebound occurs quite simply because the drug does not cure the underlying issues that led to weight gain in the first place. Owei further explained that metabolic adaptation occurs while patients are losing weight and this can contribute to weight gain when the medication is ended. She said that this effect isn’t unique to semaglutide. “This happens regardless of what weight loss method is employed,” she said, pointing out a study showing that contestants of the TV show “The Biggest Loser” had experienced a decrease in resting metabolic rate that still persisted 6 years after the competition had ended.

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Eat plenty of soluble fiber. ... Avoid foods that contain trans fats. ... Don't drink too much alcohol. ... Eat a high protein diet. ... Reduce...

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Can you take metformin with Saxenda?

Interactions between your drugs No interactions were found between metformin and Saxenda.

Major metFORMIN food Applies to: metformin

MetFORMIN should be taken with meals, and excessive alcohol intake (either short-term binge drinking or frequent consumption) should be avoided during treatment. Taking metFORMIN with alcohol may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis, which is a buildup of lactic acid in the blood that can occasionally occur during treatment with metformin-containing products. Lactic acidosis is more likely to occur if you have kidney or liver disease, acute or unstable congestive heart failure, or dehydration. You should seek immediate medical attention if you develop potential signs and symptoms of lactic acidosis such as fatigue, weakness, muscle pain, increasing drowsiness, abdominal pain or discomfort, slow or irregular heartbeat, breathing difficulty, chills, and other unusual symptoms. Alcohol may also affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. However, you should limit your alcohol intake due to the risk of lactic acidosis with metformin. Avoid drinking alcohol on an empty stomach or following exercise, as it may increase the risk of hypoglycemia. Talk to your doctor or pharmacist if you have any questions or concerns about metformin.

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