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Who should not take Mounjaro?

Mounjaro has two limitations of use: The drug isn't approved for use in people with type 1 diabetes. Mounjaro treatment should not be started in people who currently have pancreatitis or who've had this condition in the past.

healthline.com - Mounjaro: Uses, Side Effects, Dosage, and More - Healthline

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Some important things to discuss with your doctor when considering treatment with Mounjaro include:

your overall health

any medical conditions you may have

Additionally, tell your doctor if you’re taking any medications. This is important to do because some medications can interfere with Mounjaro.

These and other considerations to discuss with your doctor are described below.

Interactions

Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. These effects are called interactions. Before using Mounjaro, be sure to tell your doctor about all medications you take (including prescription and over-the-counter types). Also describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions these items may cause with Mounjaro.

Interactions with drugs or supplements

Mounjaro can interact with several types of drugs. These drugs include:

insulins such as insulin glargine (Lantus, Basaglar), or insulin lispro (Humalog)

sulfonylureas such as glipizide (Glucotrol XL), glyburide, or glimepiride (Amaryl)

warfarin (Jantoven)

birth control pills such as ethinyl estradiol/norethindrone (Junel)

This list does not contain all types of drugs that may interact with Mounjaro. Your doctor or pharmacist can tell you more about these interactions and any others that can occur with Mounjaro.

Boxed warning

Mounjaro has a boxed warning . This is a serious warning from the Food and Drug Administration (FDA) about drug effects that may be dangerous. Risk of thyroid cancer. Using Mounjaro may raise the risk of developing thyroid cancer. In animal studies, animals given Mounjaro had an increased risk of thyroid cancer. But it’s not known if Mounjaro could cause thyroid cancer, specifically medullary thyroid cancer (MTC), in humans. If you or a family member has a history of MTC or if you’ve had multiple endocrine neoplasia syndrome type 2 (MEN 2), tell your doctor before using Mounjaro. Due to the associated risks, your doctor will likely recommend a different treatment option for you. During your Mounjaro treatment, you should watch for symptoms of thyroid. These symptoms may include:

a lump or swelling in your neck

trouble swallowing

trouble breathing

hoarse voice

Your doctor may also recommend that you have certain blood tests or ultrasounds done to check your thyroid throughout your treatment. If you have questions about the risk of thyroid cancer with Mounjaro, talk with your doctor or pharmacist.

Other warnings

Mounjaro may not be right for you if you have certain medical conditions. These are known as drug-condition interactions. Other factors may also affect whether Mounjaro is a good treatment option for you. Talk with your doctor about your health history before you use Mounjaro. Factors to consider include those described below.

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Pancreatitis. Mounjaro can cause pancreatitis. If you’ve had this condition before, your risk of developing pancreatitis with Mounjaro may be higher. Before using Mounjaro, talk with your doctor about whether Mounjaro is safe for you to use. Kidney problems. Mounjaro can cause dehydration that leads to kidney problems. If you already have problems, using Mounjaro could worsen your condition. Before using this drug, talk with your doctor. If they prescribe Mounjaro, your doctor may monitor your kidney closely during your treatment. Diabetic retinopathy. If you have a vision problem called diabetic retinopathy, using Mounjaro could make it worse. If you have this condition, talk with your doctor before starting your Mounjaro treatment. Your doctor may monitor your vision more closely during your treatment. Severe digestion problems. Before starting treatment with Mounjaro, tell your doctor if you have any severe digestion problems, such as gastroparesis Mounjaro has not been studied in people who have severe digestive problems, so your doctor will likely recommend a different treatment option for you. Allergic reaction. If you’ve had an allergic reaction to Mounjaro or any of its ingredients, your doctor will likely not prescribe Mounjaro. Ask them what other medications are better options for you.

Mounjaro and alcohol

It should be safe to drink alcohol during your Mounjaro treatment. But combining Mounjaro with alcohol could make certain side effects of Mounjaro worse. You may have a higher risk of these side effects if you drink alcohol during your Mounjaro treatment. Drinking alcohol can also cause low blood sugar in people with diabetes. This can become serious if not treated quickly. If you drink alcohol, talk with your doctor about how much may be safe to drink with your condition and treatment plan.

Pregnancy and breastfeeding

Your doctor will likely recommend that you don’t use Mounjaro during pregnancy. It’s possible that Mounjaro may cause harm to a fetus. It’s important to note that untreated diabetes during pregnancy can cause problems with fetal development (commonly known as birth defects) or pregnancy loss. If you’re pregnant or planning to become pregnant, talk with your doctor about the best treatment option for you. Your doctor will also likely recommend that you don’t use Mounjaro while breastfeeding. It’s not known if the drug may pass into breastmilk or what effects it could have on a breastfed child. If you’re breastfeeding or planning to breastfeed, talk with your doctor before using Mounjaro.

healthline.com - Mounjaro: Uses, Side Effects, Dosage, and More - Healthline

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