Who Cannot use Wegovy?

If you or a family member have a history of medullary thyroid carcinoma (MTC), you shouldn't use Wegovy. MTC is a rare type of thyroid cancer. You also shouldn't use Wegovy if you have multiple endocrine neoplasia syndrome type 2 (MEN2). MEN2 is a rare genetic (inherited) condition that can cause thyroid cancer.

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Wegovy can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Wegovy. These lists do not include all possible side effects. For more information about the possible side effects of Wegovy, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome. Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Wegovy, you can do so through MedWatch.

Mild side effects

Mild side effects* of Wegovy can include:

Most of these side effects may go away within a few days to a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist. * This is a partial list of mild side effects from Wegovy. To learn about other mild side effects, talk with your doctor or pharmacist, or view Wegovy’s prescribing information.

Serious side effects

Serious side effects from Wegovy aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include:

* For more information about this side effect, see “Side effect details” below. † Wegovy has a boxed warning for this side effect. A boxed warning is the strongest warning required by the FDA. It alerts doctors and patients about drug effects that may be dangerous. Suicide prevention If you know someone at immediate risk of self-harm, suicide, or hurting another person: Ask the tough question: “Are you considering suicide?”

Listen to the person without judgment.

Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.

Stay with the person until professional help arrives.

Try to remove any weapons, medications, or other potentially harmful objects. If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988. Click here for more links and local resources.

Side effect details

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Here’s some detail on certain side effects this drug may cause.

Risk of thyroid cancer

Wegovy may cause thyroid cancer. In fact, Wegovy has a boxed warning for this risk. A boxed warning is the most serious warning from the FDA. It alerts doctors and patients about drug effects that may be dangerous. Animal studies found an increased risk of thyroid cancer in rats that were given Wegovy. But animal studies don’t always predict what will happen in humans. It isn’t known for sure if Wegovy increases the risk of thyroid cancer in humans. If you or a family member have a history of medullary thyroid carcinoma (MTC), you shouldn’t use Wegovy. MTC is a rare type of thyroid cancer. You also shouldn’t use Wegovy if you have multiple endocrine neoplasia syndrome type 2 (MEN2). MEN2 is a rare genetic (inherited) condition that can cause thyroid cancer.

Symptoms of thyroid cancer can include:

Tell your doctor right away if you have any symptoms of thyroid cancer. They can advise on the cause of these symptoms and recommend treatment options for your condition.

Pancreatitis

Pancreatitis (inflammation of the pancreas) is a rare but serious side effect of Wegovy. To find out how often this side effect occurred in clinical studies, see the drug’s prescribing information.

Symptoms of pancreatitis can include:

pain in the center of the abdomen (belly), which may get worse after eating

nausea or vomiting

diarrhea

loss of appetite

jaundice (yellowing of the skin or whites of the eyes)

Tell your doctor right away if you have symptoms of pancreatitis while taking Wegovy. They’ll check you for this condition. If you have pancreatitis, they’ll likely prescribe a drug other than Wegovy for you.

Gallbladder problems

Gallbladder problems, such as gallstones (lumps in the gallbladder), are a rare but serious side effect of Wegovy. To find out how often these side effects occurred in clinical studies, see the drug’s prescribing information.

Symptoms of gallstones may include:

abdominal (belly) pain

jaundice (yellowing of the skin or whites of the eyes)

If you have symptoms of gallbladder problems while taking Wegovy, talk with your doctor. They’ll give you tests to check for this condition. Your doctor can advise if it’s safe for you to keep taking Wegovy.

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