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Where does pannus begin?

Early in the disease, pannus is most likely to develop in small joints, such as those in the hands, wrists, and feet. Pannus can also appear in other, larger joints, such as the knees and shoulders.

arthritis-health.com - What Is Pannus? | Arthritis-health

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Rheumatoid arthritis (RA) symptoms include swollen joints that may feel spongy when the skin over them is pressed. This spongy feeling is caused by pannus, an abnormal tissue that develops because of excess inflammation. Pannus leads to painful arthritis symptoms as well as the destruction of joint cartilage and bone. A rheumatoid pannus is abnormal tissue between the bones of the joint. Watch: Rheumatoid Arthritis Overview Video This article discusses the formation of rheumatoid pannus, how it contributes to joint pain and damage, and how it is treated.

How Medical Professionals Describe Pannus

Most of the joints in the body are surrounded by a thin, delicate lining. If the lining of a joint becomes inflamed, it is called pannus. Pannus can grow out of control, covering the surfaces of a joint’s bones and cartilage. The pannus releases fluids and chemicals that can eat away those tissues. Pannus is a hallmark sign of rheumatoid arthritis. Doctors will look for indications of pannus during diagnosis, checking for spongy or boggy joints. Early in the disease, pannus is most likely to develop in small joints, such as those in the hands, wrists, and feet. Pannus can also appear in other, larger joints, such as the knees and shoulders.

See What Is Cartilage?

Pannus in other types of arthritis

It is not unusual for pannus to develop in joints affected by other types of inflammatory arthritis, such as psoriatic arthritis and lupus. However, rheumatoid pannus is typically much more severe and more damaging.

Pannus in other parts of the body

The term pannus is not exclusive to joints. Pannus is Latin for cloth or garment. In medicine, pannus is any abnormal tissue that:

Contains blood vessels (necessary for tissue growth)

Covers up a normal body structure

For example, doctors may use the term pannus to describe a thin film that grows over the eye’s cornea as a result of chronically severe dry eyes Zhang X, M VJ, Qu Y, He X, Ou S, Bu J, Jia C, Wang J, Wu H, Liu Z, Li W. Dry Eye Management: Targeting the Ocular Surface Microenvironment. Int J Mol Sci. 2017 Jun 29;18(7):1398. doi: 10.3390/ijms18071398. PMID: 28661456; PMCID: PMC5535891. or a past eye injury. Jakobiec FA, Stacy RC, Mendoza PR, Chodosh J. Hyperplastic corneal pannus: an immunohistochemical analysis and review. Surv Ophthalmol. 2014 Jul-Aug;59(4):448-53. doi: 10.1016/j.survophthal.2013.10.005. Epub 2013 Oct 20. PMID: 24309126.

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