When is Mounjaro going to be approved for weight loss?

As of May 2022, Mounjaro™ is FDA-approved for use in patients with type-2 diabetes mellitus and not for weight loss alone. However, there is proof that its active ingredient is safe and effective in treating overweight or obesity.

joincalibrate.com - Mounjaro™ (tirzepatide) for Weight Loss - Calibrate

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Is Mounjaro™ really all that special? All signs point to yes.

Results of the drug’s clinical trials were making headlines even prior to its FDA approval, and for good reason: Tirzepatide has, in two separate studies, blown some of its competitors out of the water. Read more about these trials—and their outcomes—below.

SURPASS-2 clinical trial

In a 2021 head-to-head trial, Eli Lilly’s Mounjaro™ was found to be more effective at controlling blood sugar and helping patients lose weight than Novo Nordisk’s Ozempic® (semaglutide). This SURPASS-2 trial took place over the course of 40 weeks and participants saw, on average, A1C reductions of up to 2.30 percentage points vs. their baseline. This was compared to a 1.86 percentage point reduction achieved with semaglutide. Perhaps even more interestingly, the same trial concluded that reductions in body weight were greater with tirzepatide than with semaglutide: Up to 5.5 kg more weight loss was seen with the former. Researchers hypothesize that this has to do with the medications’s unique dual action. A summary published in the New England Journal of Medicine states, “In patients with type 2 diabetes, a single molecule combining the glucose-dependent insulinotropic polypeptide receptor and GLP-1 receptor agonist may have a greater effect on glucose levels and weight control than selective GLP-1 receptor agonists.”

SURMOUNT-1 clinical trial

In the widely-publicized SURMOUNT-1 trial, Mounjaro™ was examined specifically for weight loss and the treatment of obesity. It did not disappoint: At week 72, average weight loss was 15.0% for those on a 5 mg dose, 19.5% for those on a 10 mg dose, and 20.9% for those on a 15 mg dose. This was compared to weight loss of only 3.1% in participants taking a placebo.

Other trials and research

In an earlier study completed in 2018, doses of Lilly’s tirzepatide were pitted against dulaglutide—a.k.a. Trulicity®—and “showed significantly better efficacy with regard to glucose control and weight loss than did dulaglutide, with an acceptable safety and tolerability profile.” Side effects with tirzepatide were similar to those of dulaglutide and, in general, well tolerated. Other trials of Mounjaro™ compared tirzepatide against a placebo or against more traditional therapies, including two long-acting insulin analogs. In all cases, tirzepatide at the highest dose of 15 mg/week has outperformed its opponents in A1C reduction and in overall weight loss.

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Does insurance cover Ozempic for weight loss?

Insurance won't cover Ozempic, Rybelsus and Wegovy for Weight Loss? Since the medication semaglutide was first developed for the treatment of type 2 Diabetes, many insurances still will not cover the prescription, brand name or generic, for weight loss.

forumhealth.com - Why You Don't Need Insurance to Make Semaglutide Weight Loss ...

Achieving a healthy weight is important for long-term health and is associated with a reduced risk of cardiovascular disease, diabetes, and related diseases. However, many people struggle with losing weight and keeping it off with diet and exercise alone. Finally, a drug that is addressing chronic weight management and obesity, and delivering results! A recent study showed that adults with obesity had a mean weight loss of 14.9 percent with Semaglutide as an adjunct to lifestyle intervention. Known under the brand names Ozempic, Rybelsus and Wegovy, Semaglutide is a glucagon-like peptide-1 receptor agonist. It mimics hormones in the body that are responsible for increasing insulin secretion. It was originally developed as a medication for type 2 Diabetes but its benefits for weight loss have gained it huge popularity. When Semaglutide is administered at a higher dose, it suppresses appetite in the brain. Making it an effective solution for weight loss.

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