Tropical Weight Loss
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What should you not drink with phentermine?

Patients are generally advised against using alcohol and phentermine in conjunction with one another. The side effects of combining alcohol and phentermine are likely to be more severe than those of either substance used on its own.

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About Mounjaro™ (tirzepatide) injection1 As the first and only FDA-approved GIP and GLP-1 receptor agonist, Mounjaro is a single molecule that...

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Mixing Alcohol and Phentermine

Patients are generally advised against using alcohol and phentermine in conjunction with one another. The side effects of combining alcohol and phentermine are likely to be more severe than those of either substance used on its own. For example, phentermine side effects include dry mouth, nausea, sleep disturbances, and elevated heart rate and blood pressure. All of these can be made worse when the two substances are combined. Moreover, because alcohol is known to irritate the stomach, gastrointestinal side effects are common amongst those who drink while taking phentermine. This action can lead to nausea, vomiting, stomach aches, and heartburn. The manufacturers of phentermine caution that when consuming alcohol and phentermine, you may be at an increased risk of cardiovascular side effects, including chest pains and elevated blood pressure. Also, even having only a small amount of alcohol can increase the risk of heart attack or stroke in those who are obese or have heart disease and are using phentermine. Using alcohol and phentermine together can increase the risk of addiction to both substances. Both substances are addictive on their own, and, if used together, they may be more likely to be abused. Phentermine and alcohol have two competing effects on the body. Phentermine is a central nervous system stimulant, and alcohol is a depressant. Therefore, when a person combines alcohol and phentermine, the medication may not be as effective as it would have been otherwise. In fact, there are many ways that alcohol can undermine weight loss efforts. For one, alcohol contains a large amount of sugar and mostly empty calories. Also, it tends to make people tired and less likely to be physically active—both while drinking and the day after during a hangover. Because alcohol affects the liver, it may also make it more difficult for the body to burn fat. Finally, alcohol reduces inhibitions, and a person who is drinking may be more likely to make dietary food choices. It is best for a patient who is using phentermine to stop drinking alcohol to minimize these risks and prevent other complications from occurring.

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Does phentermine mess with dopamine?

Phentermine is an amphetamine and can lead to dopamine depletion.

Congratulations to Drs. Ryan Barmore, Christopher Hess, Nikolaus McFarland and Michael Okun on the publication of “A Case of Tardive Dyskinesia and Parkinsonism Following Use of Phentermine for Weight Loss” in the April edition of Neurology. Background: Tardive dyskinesia is a movement disorder characterized by the delayed onset of involuntary muscle movements usually following use of dopaminergic antagonists. It can be associated with several other classes of medications including both prescribed and illicit stimulants. Phentermine is an amphetamine that is approved for weight loss but only with short-term use. Results: We present the case of a 56-year-old man with a history of depression and obesity who presented with the complaint of unilateral tremor and tongue thrusting. He was on no medication. On exam, his mental status was notable only for impaired delayed recall. He had repetitive tongue thrusts, of which he was unaware. He had a 4–6 Hz resting tremor in his right hand. He had mild bradykinesia and rigidity in his right upper extremity. He had normal strength and sensation throughout. He had no axial or appendicular ataxia. His gait was normal and he had no retropulsion on pull testing. A MRI brain was normal. He had no history of dopamine replacement or dopamine antagonist use. His father had Parkinson’s disease but it occurred late in life. His tongue thrusting and rest tremor had arisen following a two-month trial of phentermine which was

prescribed for weight loss.

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