What should I take after phentermine?

There are 3 drugs that are approved for long-term use now and are allowed to be used after phentermine, but the therapy should be continuous, which means you have to go straight into one of these medications the month after you finish your phentermine. ... The 3 choices are: Contrave. Belviq. Qsymia.

loseweightcincy.com - Weight Loss Medications After Phentermine-What's Available?

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Weight loss medications like phentermine, or Adipex, have been around for many years and can be very effective when used in a monitored regimen. We utilize it frequently in our practice and see excellent results, however in Ohio patients are only allowed to be on phentermine for 3 consecutive months. Frequently we will do phentermine therapy for the allowed 90 days and then switch a patient over to one of the new drugs that is approved for long-term use. So what are your options?

The 3 choices are:

Contrave

Belviq

Qsymia

Qsymia is usually my first choice, primarily because it comes in four different strengths, which allows for greater dosing flexibility. It also contains a small amount of phentermine, so we know that patients who have done well on pure phentermine will likely tolerate and lose weight with Qsymia. The smaller dose typically yields significantly less appetite suppression than the what the patient has been accustomed to, so don’t expect the same speed of weight loss with Qsymia! The cost of the medication from the pharmacy is usually around $100-$125/month with the manufacturer’s coupon. Contrave is probably also one of my favorites because it can be used for maintenance of weight loss regardless of the patients body mass index. We have coupons here in the office so that patients can get the medication for around $100/month (depending on the pharmacy and insurance coverage). This medication causes nausea with alcohol and cannot be used with many anti-depressants. Patients who take Contrave and follow a dedicated regimen of healthy eating and exercise typically lose about 3-5 pounds per month. Belviq is usually my final choice, and runs also around $100/month with the manufacturer’s coupon. It is a single-agent appetite suppressant that is not a stimulant. It also can have interactions with some anti-depressants but has fewer issues than Contrave. Patients typically see weight loss in the range of 3-5 pounds per month with Belviq also. There is also an injectable drug called Saxenda that is available for weight loss, however the expense of this drug prevents us from using it in most patients. All in all, these drugs are less potent in terms of appetite suppression than phentermine, but because they are approved for long-term use there is potential for perhaps more weight loss in the long run than with a short course of phentermine.

Happy losing!

Dr. Trace Curry

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Which weight loss drug has received approval from the FDA?

Mounjaro, a drug approved in 2022 to treat type 2 diabetes, has also shown remarkable weight-loss effects, reducing trial participants' weight by over 20%.

diatribe.org - FDA Accelerates Review of Type 2 Drug Mounjaro for Weight Loss

Mounjaro, a drug approved in 2022 to treat type 2 diabetes, has also shown remarkable weight-loss effects, reducing trial participants’ weight by over 20%. Regulators have taken notice, granting the medication a fast-track designation for its review for the treatment of obesity. The US Food and Drug Administration (FDA) approved tirzepatide for the treatment of type 2 diabetes in May, when Eli Lilly & Co. began marketing the medication as Mounjaro. While the drug is currently approved as a glucose-lowering therapy for type 2 diabetes, participants in the SURMOUNT-1 clinical trial on a 15mg dose of tirzepatide experienced an astonishing 22.5% reduction in body weight. Lilly announced on Oct. 6 that the FDA granted tirzepatide a “fast track” review to be designated as a treatment for obesity. To receive this label, Lilly will be using data from the SURMOUNT-1 trial and the ongoing SURMOUNT-2 trial, which is investigating tirzepatide in people with type 2 diabetes who have excess weight or obesity. Although the SURMOUNT-2 trial will not be completed until April 2023, the FDA’s fast-track designation allows for rolling submission of trial data. This means the FDA can review data as it comes in, instead of waiting for the entire trial to conclude first. This expedites the review process, resulting in a potentially sooner approval date. The FDA grants these fast-track designations to medications that could fill a serious unmet medical need. With the rising rates of adult and childhood obesity, coupled with the limited options for medical treatment, tirzepatide could be a game-changer in the obesity epidemic. Currently, one of the best glucose-lowering medications for weight management is Wegovy (semaglutide), which resulted in a 14.9% reduction in body weight – significantly lower than tirzepatide’s 22.5% reduction.

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