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What medicine is the same as Ozempic?

Rybelsus and Ozempic contain the same active drug, semaglutide, but in different forms. Rybelsus comes as an oral tablet, while Ozempic is given as a subcutaneous injection. Both Rybelsus and Ozempic are brand-name medications.

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Introduction Rybelsus (semaglutide) and Ozempic (semaglutide) are prescription medications. They’re both approved by the Food and Drug Administration (FDA) to help control blood sugar levels in adults with type 2 diabetes. Rybelsus and Ozempic contain the same active drug, semaglutide, but in different forms. Rybelsus comes as an oral tablet, while Ozempic is given as a subcutaneous injection. Both Rybelsus and Ozempic are brand-name medications. Generic versions of the drugs aren’t currently available. This article contains information about the main differences between Rybelsus and Ozempic. If you’re thinking about your treatment options, these details can help you consider whether one of these drugs may be right for you. Note: For more comprehensive information about these two drugs, see our Rybelsus and Ozempic articles. Ingredients of Rybelsus and Ozempic Both Rybelsus and Ozempic contain the active ingredient semaglutide. They belong to a class of drugs called glucagon-like peptide-1 (GLP-1) agonists. A class of drugs is a group of medications that act in a similar way. Effectiveness of Rybelsus vs. Ozempic Rybelsus and Ozempic have different FDA-approved uses, but they’re both used to treat type 2 diabetes when used in combination with diet and exercise. These drugs haven’t been directly compared in clinical studies. However, both Rybelsus and Ozempic have been found effective for helping improve blood sugar levels in people with type 2 diabetes when used with diet and exercise. For information about how these drugs performed in clinical studies, see the prescribing information for Rybelsus and Ozempic. Rybelsus and Ozempic are both a type of drug called a glucagon-like peptide-1 (GLP-1) agonist. GLP-1 agonists such as Rybelsus and Ozempic are included in American Diabetes Association (ADA) guidelines for treating type 2 diabetes. These guidelines recommend GLP-1 agonists as an additional treatment option when metformin doesn’t lower blood sugar enough. The ADA guidelines also recommend a GLP-1 agonist for people who have type 2 diabetes in addition to heart disease. However, the ADA recommends only drugs with proven heart benefits and FDA-approval for this use. Rybelsus is not FDA-approved for this purpose. Cost of Rybelsus vs. Ozempic How much Rybelsus or Ozempic costs depends on the treatment plan your doctor prescribes, your insurance plan, and your pharmacy. Rybelsus and Ozempic are both brand-name drugs. There are currently no generic forms of either drug. Brand-name medications usually cost more than generics. Dosage, forms, and administration Rybelsus comes as an oral tablet that you swallow. Ozempic comes as a prefilled pen that you use to give yourself a subcutaneous injection. The injections will be in your belly, thigh, or upper arm. Dosage differences between Rybelsus and Ozempic With Rybelsus, you’ll usually take 3 milligrams (mg) once per day for the first 30 days. After that, your doctor will typically increase your dose to 7 mg once per day. This is the dose that’s usually needed to help improve blood sugar management. After you’ve been taking 7 mg of Rybelsus for 30 days, your doctor will decide whether to increase the dose. If you could benefit from better blood sugar management, they may increase your dose to 14 mg, once per day. With Ozempic, you’ll usually start with a 0.25-mg injection once a week. After 4 weeks, your doctor will likely increase your dose to a 0.5-mg injection once a week. If you could benefit from better blood sugar management, your doctor may increase your dose to a 1-mg injection once a week.

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Warnings of Rybelsus and Ozempic Rybelsus and Ozempic may not be right for you if you have certain medical conditions or other factors that affect your health. Here, these are referred to as warnings. The two drugs share some of the same warnings, but they also have different ones. Some of these warnings are mentioned below. Before you start using Rybelsus or Ozempic, be sure to talk with your doctor to see if these warnings apply to you. Boxed warning: Risk of thyroid tumors Both Rybelsus and Ozempic have a boxed warning . This is the most serious warning from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous. In animal studies of Rybelsus and Ozempic, semaglutide increased the risk of thyroid C-cell tumors. (Semaglutide is the active drug in both Rybelsus and Ozempic.) It’s not known if these medications increase the risk of thyroid tumors in humans. You shouldn’t take Rybelsus or Ozempic if you or a family member have ever had a type of thyroid cancer called medullary thyroid carcinoma. You also shouldn’t take these drugs if you have a rare form of cancer called multiple endocrine neoplasia syndrome type 2. If you develop symptoms of thyroid cancer while taking Rybelsus or Ozempic, see your doctor right away. Symptoms may include trouble swallowing, hoarseness that doesn’t get better, shortness of breath, and a lump in your neck. Other warnings In addition to boxed warnings, Rybelsus and Ozempic have other warnings. Before using Rybelsus or Ozempic, talk with your doctor if any of the following conditions or health factors apply to you: if you’ve had an allergic reaction to either drug or any of its ingredients

if you’re pregnant or breastfeeding

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if you have a history of pancreatitis

if you have kidney problems, such as kidney failure

if you have ever been diagnosed with diabetic retinopathy (an eye condition caused by diabetes) To learn more about these drugs, see the in-depth articles on Rybelsus and Ozempic. Switching between Rybelsus and Ozempic Your doctor may switch you to Rybelsus from Ozempic if you prefer taking medication by mouth instead of having subcutaneous injections. Or they may switch you to Ozempic from Rybelsus if you prefer taking a drug once a week instead of once per day. If you have heart disease, your doctor may recommend Ozempic instead of Rybelsus. Ozempic is approved to decrease the risk of major heart problems in people with type 2 diabetes and heart disease. Rybelsus isn’t approved for this use. If you’re taking 14 milligrams (mg) of Rybelsus once per day, your doctor may switch you to a 0.5-mg injection of Ozempic once a week. You can start having your Ozempic injections the day after your last dose of Rybelsus. If you’re taking a 0.5-mg injection of Ozempic once a week, your doctor may switch you to either a 7-mg or 14-mg dose of Rybelsus once per day. You can start taking Rybelsus up to 7 days after your last injection of Ozempic. If you’re taking 1-mg injections of Ozempic once a week, keep in mind that there’s no equal dose of Rybelsus. If you’re interested in switching between Rybelsus and Ozempic, talk with your doctor. You shouldn’t switch your medications without your doctor’s approval and guidance.

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