What is the skinny hormone?

Leptin is a hormone secreted from fat cells that helps to regulate body weight. The name leptin is derived from the Greek word 'leptos' meaning thin. It is sometimes referred to as the 'Fat Controller'. Kisspeptin Luteinising hormone Glossary All Hormones Resources for Hormones.

yourhormones.info - Leptin | You and Your Hormones from the Society for Endocrinology

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Alternative names for leptin

There are no other names used for the hormone but the gene, which encodes leptin, is known as the 'ob' gene.

What is leptin?

Leptin is a hormone released from fat cells in adipose tissue. Leptin signals to the brain, in particular to an area called the hypothalamus. Leptin does not affect food intake from meal to meal but, instead, acts to alter food intake and control energy expenditure over the long term. Leptin has a more profound effect when we lose weight and levels of the hormone fall. This stimulates a huge appetite and increased food intake. The hormone helps us to maintain our normal weight and unfortunately for dieters, makes it hard to lose those extra pounds!

How is leptin controlled?

Because leptin is produced by fat cells, the amount of leptin released is directly related to the amount of body fat; so the more fat an individual has, the more leptin they will have circulating in their blood. Leptin levels increase if an individual increases their fat mass over a period of time and, similarly, leptin levels decrease if an individual decreases their fat mass over a period of time.

What happens if I have too much leptin?

Obese people have unusually high levels of leptin. This is because in some obese people, the brain does not respond to leptin, so they keep eating despite adequate (or excessive) fat stores, a concept known as ‘leptin resistance’. This causes the fat cells to produce even more leptin. This is similar to the way people with type 2 diabetes have unusually high levels of insulin, as their body is resistant to the effects of insulin. The cause of leptin resistance is still unclear.

What happens if I have too little leptin?

There is an extremely rare condition called congenital leptin deficiency, which is a genetic condition in which the body cannot produce leptin. In the UK, there are only about four families affected by this genetic condition. Absence of leptin makes the body think it does not have any fat whatsoever and this results in uncontrolled food intake and severe childhood obesity. In addition, leptin deficiency may cause delayed puberty and poor function of the immune system. This condition can be well treated by leptin injections, which cause dramatic weight loss.

Last reviewed: Mar 2018

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Is eating 1 meal a day OK?

Safety Concerns For most people, there are no serious dangers involved in eating one meal a day, other than the discomforts of feeling hungry. That said, there are some risks for people with cardiovascular disease or diabetes. Eating one meal a day can increase your blood pressure and cholesterol.

webmd.com - Is Eating One Meal a Day Safe? - WebMD

The “One Meal a Day” diet, or OMAD diet, claims to help you lose weight by forcing your body to burn fat. It’s a type of intermittent fasting, which alternates between periods throughout the day in which you can eat anything and periods in which you don’t eat at all. OMAD is particularly strict because you don’t eat for 23 hours, then consume all of your calories in a single meal. How It Works Like other kinds of intermittent fasting, eating one meal a day is a way of manipulating how your body finds and uses fuel. When you eat in a more traditional pattern, your energy comes from the food that you eat. When you take in carbohydrates, your body breaks them down into sugars. If you have more sugar in your blood than you need, a chemical called insulin will carry the extra into your fat cells. When you don’t eat for extended periods of time, your body produces less insulin. Your cells still need energy for fuel, so your fat cells release energy to compensate. For this to happen, however, you have to avoid eating for long enough that your insulin levels drop.

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