Tropical Weight Loss
Tropical Weight Loss
Photo: Gary Barnes
The study found that people who stayed on phentermine longer experienced greater weight loss than those who took the drug for three months or less, and longer-term use was not associated with increases in blood pressure or increased risk of heart attack, stroke or death.
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Read More »An inexpensive weight-loss drug approved 60 years ago for only short-term use also may be safe and effective for longer-term treatment, according to a study conducted by researchers at Wake Forest Baptist Health and the Patient Outcomes Research to Advance Learning (PORTAL) network. The study is published in today's issue of the journal Obesity. The drug, phentermine, is currently FDA-approved for use of up to three months. "Although diet and exercise are critical components of any weight-loss program, up to half of patients don't have long-term success with lifestyle changes alone," said first author Kristina H. Lewis, M.D., assistant professor of epidemiology and prevention, at Wake Forest Baptist. "In those cases, medications or surgery can help. Generic phentermine is an effective and affordable option, but now that we view obesity as a chronic disease, it's important to have medications that can be used indefinitely. Most new weight-loss drugs are approved for long-term use, but unfortunately the newer drugs can be expensive if they are not covered by insurance." Lewis and her team analyzed data from the electronic health records of 13,972 adults who were prescribed phentermine for short-term use versus longer-term use of a year or more. The researchers compared weight loss and changes in blood pressure for up to two years, and the risk of heart attack, stroke or death for up to three years, according to a patient's duration of medication use. The study found that people who stayed on phentermine longer experienced greater weight loss than those who took the drug for three months or less, and longer-term use was not associated with increases in blood pressure or increased risk of heart attack, stroke or death. "In general, the longer patients were on the medicine the more weight loss they had," Lewis said. "Not surprisingly, when patients stopped taking the medicine weight regain was common." However, Lewis cautioned that phentermine is a stimulant and should not be used in people with a history of heart disease, stroke or uncontrolled high blood pressure. But for those with low cardiac risk, normal blood pressure or high blood pressure that is well treated, it could be a good and affordable option, she said. "For patients who respond to and tolerate it, phentermine may be a safe and affordable way to achieve greater and longer lasting weight loss, but we need clinical trials to provide more certainty," Lewis said. "At the moment, there is no change to the FDA labeling so doctors should use caution with the decision about prescribing it longer-term." The study did not examine the most effective dose of the drug or potential side effects such as anxiety or insomnia. In addition, the people in the study did not have evidence of pre-existing heart disease and most were young or middle-aged women. Support for the research was provided by Patient-Centered Outcomes Research Institute as part of PORTAL project CDRN 1306-04681.
Elevated levels of ghrelin in the blood can lead to weight gain. Obese people are particularly sensitive to ghrelin, encouraging them to eat more....
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If you are hungry between 7 p.m. and whenever you go to bed, try to stick to water or a healthy, low calorie snack (like carrots). Always try to...
Read More »Supplements for Weight Loss Chitosan. Chromium Picolinate. Conjugated Linoleic Acid (CLA) Glucomannan. Green Tea Extract. Green Coffee Extract. Guar Gum. Hoodia. More items... •
When you want to drop some weight, it's tempting to look for help anywhere you can. If your thoughts turn to supplements or herbal remedies, keep in mind that research gives many of them mixed reviews. In some cases, there isn't a lot of science to back up the claims, and some have health risks. Talk with your doctor first before you try any. Also, you should know that the FDA has cracked down on some weight loss supplements that had prescription drugs in them that weren't noted on the label. You can't always tell what you're getting. Supplements are not regulated by the FDA in the same way that food and drugs are. The FDA does not review these supplements for safety or efficacy before they hit the market. Chitosan This is a sugar that comes from the hard outer layers of lobsters, crabs, and shrimp. Enthusiasts say it can block fats and cholesterol from getting absorbed by your body. Does it help you lose weight? Natural Medicines, an independent group that analyzes research on supplements, says there isn't enough reliable evidence to rate it. The National Center for Complementary and Integrative Health states that chitosan has not been shown to be effective for weight loss. Chitosan usually causes no side effects, but some people get an upset stomach or constipation. If you are allergic to shellfish, you should not take chitosan, because it is made from shellfish.
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