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What are symptoms of high histamine?

Histamine is associated with common allergic responses and symptoms. ... Symptoms of histamine intolerance headaches or migraines. nasal congestion or sinus issues. fatigue. hives. digestive issues. irregular menstrual cycle. nausea. vomiting.

healthline.com - Histamine Intolerance: Causes, Symptoms, and Diagnosis

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We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission. Here’s our process. How we vet brands and products Healthline only shows you brands and products that we stand behind. Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we: Evaluate ingredients and composition: Do they have the potential to cause harm?

Do they have the potential to cause harm? Fact-check all health claims: Do they align with the current body of scientific evidence?

Do they align with the current body of scientific evidence? Assess the brand: Does it operate with integrity and adhere to industry best practices? We do the research so you can find trusted products for your health and wellness. Read more about our vetting process. What is histamine intolerance? Histamine intolerance is not a sensitivity to histamine, but an indication that you’ve developed too much of it. Histamine is a chemical responsible for a few major functions: communicates messages to your brain

triggers release of stomach acid to help digestion

releases after injury or allergic reaction as part of your immune response When histamine levels get too high or when it can’t break down properly, it can affect your normal bodily functions. What causes high histamine levels? You naturally produce histamine along with the enzyme diamine oxidase (DAO). DAO is responsible for breaking down histamine that you take in from foods. If you develop a DAO deficiency and are unable to break down histamine, you could develop an intolerance. Some reasons your DAO enzyme levels could be affected include: medications that block DAO functions or prevent production

gastrointestinal disorders, such as leaky gut syndrome and inflammatory bowel disease

histamine-rich foods that cause DAO enzymes to function improperly

foods that block DAO enzymes or trigger histamine release Bacterial overgrowth is another contributing factor for developing a histamine intolerance. Bacteria grows when food isn’t digested properly, causing histamine overproduction. Normal levels of DAO enzymes can’t break down the increased levels of histamine in your body, causing a reaction. Diagnosing histamine intolerance Before reaching a diagnosis, your doctor will eliminate other possible disorders or allergies that cause similar symptoms. Doctors may also suggest following an elimination diet for 14 to 30 days. This diet requires you to remove any foods high in histamine or histamine triggers, and slowly reintroduce them to watch for new reactions. Your doctor might also take a blood sample to analyze if you have a DAO deficiency. Another way to diagnose histamine intolerance is through a prick test. A 2011 study examined the effectiveness of a prick test to diagnose histamine intolerance. Researchers pricked the skin of 156 people and applied a 1 percent histamine solution. For those with suspected histamine intolerance, the prick test was positive for 79 percent, revealing a small red, itchy bump on the tested area that didn’t resolve within 50 minutes.

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