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What age is phentermine approved for?

FDA approves treatment for chronic weight management in adolescents aged 12 years and older. Recently, the FDA announced the approval of supplemental indication for phentermine and topiramate extended-release capsules for chronic weight management in children aged 12 years and older.

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Recently, the US Food and Drug Administration (FDA) announced it has approved a supplemental indication for phentermine and topiramate extended-release capsules (Qsymia; Vivus LLC) for chronic weight management in pediatric patients aged 12 years and older considered obese. Obese is defined as a body mass index (BMI) of 95th percentile or greater when standardized for age and sex. The drug should be as supplemental therapy in addition to a reduced-calorie diet and increased physical activity. Currently, 21% of US adolescents (1 in 5) are considered obese, a percentage that has increased over the last 50 years. As pediatric obesity is a serious condition that may adversely impact health, the FDA recommends lifestyle medication as first-line therapy, or if lifestyle intervention is not effective, medication may be considered. The FDA originally approved phentermine and topiramate extended-release capsules in July 2012 for chronic weight management in adults with an “initial BMI of 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least 1 weight-related comorbidity such as hypertension, type 2 diabetes mellitus, or dyslipidemia, as an adjunct to a reduced-calorie diet and increased physical activity,” according to the press release announcing the approval. The safety and efficacy of phentermine and topiramate extended-release capsules was evaluated in a 56-week, double-blind, placebo-controlled study of adolescents aged 12 to less than 17 years old. The study participants—223 in total—included had a BMI at the 95th percentile or greater for their age and sex and were unable to lose weight or maintain weight loss with changes in eating or exercise. Randomized participants were assigned to receive the drug at doses 7.5 mg/46 mg (n = 54), 15 mg/ 92 mg (n = 113), or placebo (n = 56) once a day after a titration period to their assigned dose. Additionally, they were all counselled in lifestyle changes including eating habits and increased exercise. Study results showed that those taking the drug at doses 7.5 mg/46 mg and 15 mg/ 92 mg lost an average of 4.8% and 7.1% of their BMI, respectively. In comparison, participants receiving placebo gained an average of 3.3% of their BMI.

Reference:

FDA approves treatment for chronic weight management in pediatric patients aged 12 years and older. US Food and Drug Administration. Published June 27, 2022. Accessed June 28 2022. https://www.fda.gov/drugs/news-events-human-drugs/fda-approves-treatment-chronic-weight-management-pediatric-patients-aged-12-years-and-older/?utm_medium=email&utm_source=govdelivery

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Why am I not losing weight on 1500 calories a day?

If you're a man, woman weighing over 164 pounds or a female who regularly exercises and you aren't losing weight eating 1,200 to 1,500 calories daily, it may be time to see a doctor. Hormone imbalances – such as underactive thyroid – can decrease your body's metabolism and inhibit or prevent weight loss from occurring.

Eating 1,500 calories daily helps many adults lose weight effectively. However, some people may not notice a significant weight loss when following this type of reduced-calorie diet, at least initially. If you haven’t lost weight following a 1,500-calorie diet for a period of a few weeks, it may be time to adjust your calorie intake – or see a doctor.

Keep a Food Diary

If a 1,500-calorie diet isn’t helping you lose weight, keep a food diary to record everything you eat and drink daily. This way you can double check to make sure you are in fact eating 1,500 calories. Use nutrition facts labels and online nutrition databases – such as the U.S. Department of Agriculture National Nutrient Database – to accurately track your intake to make sure you are indeed consuming 1,500 calories.

Effective Weight Loss

According to the National Heart, Lung and Blood Institute, a 1,500-calorie diet is often appropriate for weight loss in men, women who exercise regularly and women weighing 165 pounds or more. However, some people in this population group may require as few as 1,200 calories daily, notes the NHLBI. If you aren’t losing weight eating 1,500 calories a day, try a 1,200-calorie meal plan, at least for a little whole.

Ineffective Weight Loss

Certain population groups aren’t expected to lose much weight – if any – using 1,500-calorie diets. Sedentary women weighing less than 165 pounds often require 1,000 to 1,200 calories daily for effective weight loss, notes the NHLBI. Older women may not notice much of a weight loss eating 1,500 calories daily either. The Dietary Guidelines for Americans 2010 report that sedentary women over age 50 require just 1,600 calories a day to maintain their body weight.

Seek Medical Assistance

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