Tropical Weight Loss
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FDA approves treatment for chronic weight management in adolescents aged 12 years and older. Recently, the FDA announced the approval of supplemental indication for phentermine and topiramate extended-release capsules for chronic weight management in children aged 12 years and older.
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Read More »Recently, the US Food and Drug Administration (FDA) announced it has approved a supplemental indication for phentermine and topiramate extended-release capsules (Qsymia; Vivus LLC) for chronic weight management in pediatric patients aged 12 years and older considered obese. Obese is defined as a body mass index (BMI) of 95th percentile or greater when standardized for age and sex. The drug should be as supplemental therapy in addition to a reduced-calorie diet and increased physical activity. Currently, 21% of US adolescents (1 in 5) are considered obese, a percentage that has increased over the last 50 years. As pediatric obesity is a serious condition that may adversely impact health, the FDA recommends lifestyle medication as first-line therapy, or if lifestyle intervention is not effective, medication may be considered. The FDA originally approved phentermine and topiramate extended-release capsules in July 2012 for chronic weight management in adults with an “initial BMI of 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least 1 weight-related comorbidity such as hypertension, type 2 diabetes mellitus, or dyslipidemia, as an adjunct to a reduced-calorie diet and increased physical activity,” according to the press release announcing the approval. The safety and efficacy of phentermine and topiramate extended-release capsules was evaluated in a 56-week, double-blind, placebo-controlled study of adolescents aged 12 to less than 17 years old. The study participants—223 in total—included had a BMI at the 95th percentile or greater for their age and sex and were unable to lose weight or maintain weight loss with changes in eating or exercise. Randomized participants were assigned to receive the drug at doses 7.5 mg/46 mg (n = 54), 15 mg/ 92 mg (n = 113), or placebo (n = 56) once a day after a titration period to their assigned dose. Additionally, they were all counselled in lifestyle changes including eating habits and increased exercise. Study results showed that those taking the drug at doses 7.5 mg/46 mg and 15 mg/ 92 mg lost an average of 4.8% and 7.1% of their BMI, respectively. In comparison, participants receiving placebo gained an average of 3.3% of their BMI.
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Read More »If you're a man, woman weighing over 164 pounds or a female who regularly exercises and you aren't losing weight eating 1,200 to 1,500 calories daily, it may be time to see a doctor. Hormone imbalances – such as underactive thyroid – can decrease your body's metabolism and inhibit or prevent weight loss from occurring.
Eating 1,500 calories daily helps many adults lose weight effectively. However, some people may not notice a significant weight loss when following this type of reduced-calorie diet, at least initially. If you haven’t lost weight following a 1,500-calorie diet for a period of a few weeks, it may be time to adjust your calorie intake – or see a doctor.
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