Tropical Weight Loss
Tropical Weight Loss
Photo: Alena Darmel
Losing weight isn't easy, especially without the dangerous, but actually effective weight-loss drug Fen-Phen, which the FDA pulled from shelves in 1997 due to concerns about damage the drug was doing to patients' heart valves.
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Read More »Losing weight isn't easy, especially without the dangerous, but actually effective weight-loss drug Fen-Phen, which the FDA pulled from shelves in 1997 due to concerns about damage the drug was doing to patients' heart valves. But a small drug maker, Arena Pharmaceuticals, said today at the JPMorgan Healthcare Conference that they have a compound that will work like Fen-Phen, but without the side effects. It's called lorcaserin, and halfway through its final stage of clinical trials, so far, so safe. Patients taking a 20 mg dose lost eight pounds over a twelve week study, with only minor side effects. But what's interesting for Wired readers, who, given the lack of popularity of my last story on obesity drugs, must all use diet and exercise to control their waistlines, is exactly why lorcaserin might work as well as Fen-Phen without the side effects. Each drug has a particular shape, which determines what receptors in your body it stimulates (or blocks). In the case of Fen-Phen, the fen (technically, fenfluramine) was believed to stimulate the serotonin 2C receptor, causing people to feel full, and eat less. Unfortunately, according to Arena, fen-phen also ended up stimulating the serotonin 2B receptor, which eventually led to the problems with the heart. But, the new drug from Arena attaches to the 2C receptor at 100 times the rate it attaches to the 2B receptor. So, voila, you've got fen-phen without a broken heart. But, of course, it's not really that easy. To get the slight chance in selectivity that the move from fen-phen to lorcaserine represents, it's taken hundreds of millions of dollars and at least a decade of research and testing. Those tiny differences in molecule shape are what the business of drug development has become. If Arena is able to duplicate Fen-Phen's weight-loss results without it's side effects, it could be sitting on a goldmine, with a US population is one-third obese and two-thirds overweight. And that's why there are 7500 attendees crammed into this hotel, hunting the next blockbuster drug, like the cholesterol-lowering drug Lipitor, which racked up almost $13 billion in sales for Pfizer in 2006.
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