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Is Ozempic a high risk medication?

This drug has a boxed warning about possible risk of thyroid cancer. This is the most serious warning from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous. In animals, Ozempic can increase the risk of thyroid tumors.

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Ozempic can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking Ozempic. This list does not include all possible side effects. For more information on the possible side effects of Ozempic or tips on how to manage a troubling side effect, talk with your doctor or pharmacist. You can also read this article for details about Ozempic’s potential side effects.

More common side effects

The more common side effects of Ozempic can include:

nausea*

headache

vomiting

diarrhea

stomach pain

stomach upset

constipation

flatulence (passing gas)

These side effects may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk with your doctor or pharmacist. * For more information on this side effect, see “Side effect details” below.

Serious side effects

Serious side effects from Ozempic aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects and their symptoms can include the following:

Thyroid cancer.*

Pancreatitis (inflammation of the pancreas). Symptoms can include: pain in your back and belly nausea vomiting unintended weight loss fever swollen belly Hypoglycemia (low blood sugar). Symptoms can include: drowsiness headache confusion weakness hunger irritability sweating feeling jittery fast heartbeat Diabetic retinopathy (diabetes-related eye problems). Symptoms can include: blurred vision vision loss seeing dark spots poor night vision Kidney damage. Symptoms can include: reduced urination swelling in your legs or ankles confusion fatigue nausea Gallbladder disease. Symptoms can include: gallstones, which can cause pain in your belly, nausea, vomiting, and fever cholecystitis (inflammation in your gallbladder)

Allergic reaction.*

* For more information on this side effect, see “Side effect details” below.

Side effect details

You may wonder how often certain side effects occur with this drug. Here’s some detail on some of the side effects this drug may cause.

Allergic reaction

As with most drugs, some people can have an allergic reaction after taking Ozempic. Symptoms of a mild allergic reaction can include:

skin rash

itchiness

flushing

A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

swelling under your skin, typically in your eyelids, lips, hands, or feet

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swelling of your tongue, mouth, or throat

trouble breathing

It’s not known how often allergic reactions may have occurred in people taking Ozempic in clinical trials. However, serious allergic reactions to Ozempic have been reported. Call your doctor right away if you have a severe allergic reaction to Ozempic. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Nausea

Nausea is the most common side effect of Ozempic. It’s most likely to occur when you first start taking Ozempic, and when your dosage is increased. Nausea may decrease or go away with continued use of Ozempic. If it doesn’t go away or it becomes severe, talk with your doctor.

Heartburn

Some people who take Ozempic can have heartburn, but this isn’t common. To find out how often this side effect occurred in clinical trials, see Ozempic’s prescribing information. This side effect may decrease or go away with continued use of the drug. If it doesn’t go away or it becomes severe, talk with your doctor.

Headache

Headache is a common side effect of Ozempic. This side effect may decrease or go away with continued use of the drug. If it doesn’t go away or it becomes severe, talk with your doctor.

Thyroid cancer

Ozempic has a boxed warning from the Food and Drug Administration (FDA) about possible risk of thyroid cancer. A boxed warning is the strongest warning the FDA requires. In animal studies, Ozempic increased the risk of thyroid tumors. However, it’s not known if Ozempic causes thyroid tumors in humans. There have been cases of thyroid cancer in people taking liraglutide (Victoza), a medication in the same drug class as Ozempic. However, it’s not clear if these cases were caused by liraglutide or something else. Because of the potential risk of thyroid cancer, you should not use Ozempic if you or an immediate family member have ever had a form of cancer called medullary thyroid carcinoma (MTC), or a rare endocrine condition called multiple endocrine neoplasia syndrome type 2. If you’re taking Ozempic and have symptoms of a thyroid tumor, contact your doctor right away. Symptoms can include:

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