How long does it take for B12 to work?

It may take a few weeks before your vitamin B12 levels and symptoms (such as extreme tiredness or lack of energy) start to improve. If you have hydroxocobalamin injections to boost your vitamin B12 levels at the start of treatment, the cyanocobalamin tablets may start to work within a few days.

nhs.uk - Cyanocobalamin – vitamin B12 used to treat and prevent vitamin ... - NHS

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Dosage

The amount of cyanocobalamin you need depends on the level of vitamin B12 in your blood and why your levels are low. Your doctor or pharmacist will advise you on what dose to take.

The usual dose for:

diet-related deficiency is 50 micrograms to 150 micrograms, taken once a day

is 50 micrograms to 150 micrograms, taken once a day B12 deficiency not caused by your diet is one to two 1,000 microgram tablets, taken once or twice a day – this is usually if you cannot have vitamin B12 injections

In children the doses may be lower.

If you are taking supplements that you have bought, follow the dosage instructions that come with them.

How to take it

Swallow prescribed cyanocobalamin tablets whole with a drink of water. Do not chew or break them. It’s usually best to take the tablets on an empty stomach. This means at least 2 hours after a meal or snack and at least 30 minutes before you eat again. For cyanocobalamin supplements that you buy, follow the instructions that come in the packet.

Will my dose go up or down?

To see how well your tablets are working, your doctor may ask you about symptoms such as tiredness and lack of energy. You may also have regular blood tests to monitor the levels of vitamin B12 in your blood. Your doctor may want to increase or decrease your dose of cyanocobalamin tablets depending on the level of vitamin B12 in your blood.

What if I forget to take it?

If you forget to take cyanocobalamin tablets, take your usual dose as soon as you remember, unless it’s nearly time for your next dose. In this case just leave out the missed dose and take your next one as normal. Never take more than your usual number of tablets at one time. Never take extra tablets to make up for forgotten ones. If you forget your tablets often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

What if I take too much?

Taking an extra dose of cyanocobalamin tablets is unlikely to harm you.

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Can metformin cause rapid weight loss?

Is Metformin an Effective Weight Loss Pill? No. The amount of weight you're likely to lose is low. In one diabetes prevention study, 29% of people lost 5% or more of their body weight and just 8% lost around 10%.

webmd.com - Does Metformin Cause Weight Loss? - WebMD

How Metformin Works Metformin starts to work in your gut. Some scientists think it changes the balance of the natural bacteria in your digestive system. It also turns on specific enzymes that help the body use fat more effectively. Scientists have also been trying to understand how metformin leads to weight loss. Because it alters gut bacteria, digestive issues are common side effects. So one early theory was that stomach pain caused people to lose their appetite and eat less, or that they lost water weight from diarrhea. But most of these side effects go away in a few weeks. People who lost weight on metformin continued to lose pounds after that time. A more likely explanation is that metformin’s changes in the gut tamp down appetite. It may raise the body’s levels of the hormone leptin, which makes you feel full. Since your appetite isn’t working overtime, you eat less. The weight you lose on the drug comes mostly from fat stores, not the mix of fat and lean muscle that happens with dieting. People on metformin also saw lower waist measurements and waist-to-hip ratios, two ways to measure body fat.

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