Tropical Weight Loss
Tropical Weight Loss
Photo: Julia Larson
Wellbutrin is an antidepressant that is also used to promote weight loss, compared to other antidepressants which have not been shown to produce this effect. Numerous clinical trials have reported reduced body weight in patients taking Wellbutrin, indicating it may be an effective treatment for weight loss.
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Read More »Have you considered clinical trials for Weight management? We make it easy for you to participate in a clinical trial for Weight management, and get access to the latest treatments not yet widely available - and be a part of finding a cure. Check your eligibility How does Wellbutrin work? How Wellbutrin works is still not clearly understood. Previous data shows that Wellbutrin acts on the brain’s norepinephrine and dopamine pathways¹. Clinical trial data shows that taking Wellbutrin doubled abstinence rates, both in the short and long term compared to controls or the nicotine patch, suggesting Wellbutrin to be an effective smoking cessation aid. Can you take Wellbutrin to lose weight? Although Wellbutrin is not specifically designed to support weight loss, you may experience weight loss when taking it. As there is a lack of research, it is unclear how Wellbutrin contributes to weight loss, but clinical studies have observed changes in body weight in individuals treated with Wellbutrin.² ³ ⁵ Despite its proven weight loss effects, experts consider this a side effect of its main treatment purpose. One study examined a combination therapy of naltrexone/bupropion (known as Contrave, which is commonly prescribed for obese individuals). Its findings suggest that the drugs affected brain reward pathways and other associated regions of the brain that influence food intake, cravings, and eating behaviors.⁴ Researchers concluded that this might be a potential mechanism for targeting weight loss. Clinical studies have also investigated the effects of numerous antidepressants on body weight and observed that Wellbutrin was the only antidepressant that directly resulted in weight loss.² ³ Of those who took Wellbutrin, non-smokers lost approximately seven pounds over two years, whereas patients taking other antidepressants gained weight.² Other clinical trial data shows that Wellbutrin can promote weight loss in obese patients. Sustained weight loss of 7% and 10% of initial body weight was observed in patients treated with 300 or 400mg per day of Wellbutrin, respectively, after 48 weeks of treatment.⁵ However, Wellbutrin may not be a universal weight loss treatment, as every person has unique biology and circumstances. What is right for one person may not be right for another. Clinicians will assess your history and medical condition and may recommend Wellbutrin in combination with a healthy diet and exercise to support your weight loss outcomes. Is Wellbutrin safe? The therapeutic effects of Wellbutrin are typically experienced in the second week of taking the medication.⁶ Depending on its formulation, the time it takes for optimal concentrations of Wellbutrin to enter the bloodstream differs from two, three, and five hours for immediate, sustained, and extended releases, respectively.⁶ The effect lasts for approximately one to two days, during which time you should be monitored for any serious adverse effects associated with taking this medication.⁶ Like most drugs, Wellbutrin can cause adverse effects, which have been reported to occur in over 10% of patients.¹ Common side effects may include: Headaches
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