Tropical Weight Loss
Tropical Weight Loss
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Recent research published in the journal Diabetes, Obesity and Metabolism indicates that once patients stop using semaglutide drugs like Wegovy and Ozempic any weight they've lost is likely to return.
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Read More »Share on Pinterest Taking semaglutide medication like Wegovy and Ozempic can help people lose weight, but they often regain lost pounds once they stop. Sergey Mironov/Getty Images Research has found that when people stop using semaglutide, weight rebound occurs. Experts say this is because the drug is not a cure and it does not prevent the metabolic adaptation that occurs during weight loss. Long-term changes in diet and activity are an important part of maintaining weight loss. It is also important to consult with a physician before using weight loss medications. Recent research published in the journal Diabetes, Obesity and Metabolism indicates that once patients stop using semaglutide drugs like Wegovy and Ozempic any weight they’ve lost is likely to return. According to Dr. Ibiye Owei, Assistant Professor at Texas Tech University Health Sciences Center El Paso, semaglutide is a glucagon-like-peptide-1 agonist (GLP-1 agonist) which has been approved by the Food and Drug Administration (FDA) to treat diabetes and obesity or overweight. “It works by making people feel full sooner and suppressing the appetite so people do not feel as hungry,” she explained. “One of the ways it does this is by slowing emptying of the stomach so there is a feeling of satiety.” Owei added that anyone with obesity defined as a Body Mass Index (BMI) of 30 and above or a BMI of 27 and above who is experiencing weight-related complications such as hypertension or type 2 diabetes would be a good candidate to use this medication. Semaglutide is one of the most effective treatments for obesity According to Dr. Kathleen Dungan, an endocrinologist in the Division of Endocrinology, Diabetes & Metabolism at The Ohio State University Wexner Medical Center, there are several potential benefits to using semaglutide. “It is one of the most effective treatments available for either condition, outside of bariatric surgery,” said Dungan. “Moreover, there is evidence that the use of semaglutide may reduce the risk for developing diabetes and may be particularly useful in individuals who have prediabetes.” What happens when you quit taking semaglutide While drugs like Wegovy and Ozempic might seem like a miracle to those with diabetes and obesity, the truth is the effects only last while you are taking the medication. A study published in April 2022 which sought to examine changes in body weight and cardiometabolic risk factors upon the termination of the drug, found that after a year people had regained two-thirds of the weight they had lost. The positive changes they had seen in cardiometabolic risk factors like blood pressure, blood lipids, HbA1c, and C-reactive protein had similarly reversed. According to the study authors, these findings reinforce the need to continue treatment in order to maintain the benefits of the medication. Why rebound weight gain occurs According to Dungan, weight rebound occurs quite simply because the drug does not cure the underlying issues that led to weight gain in the first place. Owei further explained that metabolic adaptation occurs while patients are losing weight and this can contribute to weight gain when the medication is ended. She said that this effect isn’t unique to semaglutide. “This happens regardless of what weight loss method is employed,” she said, pointing out a study showing that contestants of the TV show “The Biggest Loser” had experienced a decrease in resting metabolic rate that still persisted 6 years after the competition had ended.
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Read More »Since the half-life of Ozempic is about seven days6, our patient's renal function recovered after four weeks. Luckily, the kidney damage was reversible. Physicians should be aware of such potential rare complications when prescribing GLP-1 agonists and closely monitor renal function after initiation.
Glucagon-like peptide-1(GLP-1) receptor agonists play a significant role in treating type 2 diabetes and obesity. Their extended half-life allows for once-weekly injections1. Semaglutide has cardioprotective and renoprotective effects2 with decreased cardiovascular death rates, nonfatal myocardial infarction, or nonfatal stroke3. SUSTAIN 6 trial, a post hoc analysis that assessed its effects on mean estimated glomerular filtration rate (eGFR), did not show adverse renal outcomes regardless of baseline renal function4. To our knowledge, only two cases5 report acute kidney injury (AKI) that developed on a background of chronic kidney disease after starting semaglutide6. We discuss a patient with normal kidney function who developed AKI after starting Semaglutide.
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