Tropical Weight Loss
Tropical Weight Loss
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The FDA approved Ozempic for a 2.0 mg dose, which was based on clinical trial data showing the higher dose led to a better A1C and to weight loss.
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Read More »The FDA approved Ozempic for a 2.0 mg dose, which was based on clinical trial data showing the higher dose led to a better A1C and to weight loss. The FDA recently approved Novo Nordisk’s 2.0 mg dose of the once-weekly injectable Ozempic (semaglutide) based on results from the SUSTAIN FORTE clinical trial. Ozempic 2.0 mg, a GLP-1 receptor agonist, previously only available at the 0.5 mg and 1.0 mg doses, is now approved for type 2 diabetes and to reduce the risk of heart attack, stroke, or cardiac death in adults with type 2 diabetes and with heart disease. The SUSTAIN FORTE clinical trial showed better outcomes over 40 weeks for the 2.0 mg dose compared to the 1.0 mg dose. However, negative gastrointestinal side effects did occur more frequently among patients receiving the higher dose (34% compared to 30.8%). 2.0 mg dose group 1.0 mg dose group Average A1C at the start of the Trial 8.9% 8.8% Average A1C at 40 weeks 6.7% 6.9% Average reduction in A1C 2.2 percentage points 1.9 percentage points Percent of group achieving an A1C of 6.5% or lower 52% 39% Percent of group who had at least 5% weight reduction 59% 51% Percent of group who had at least 10% weight reduction 28% 23% Two other drugs, Rybelsus or Wegovy, are similar to Ozempic; all three of these medications are different forms of semaglutide. Rybelsus is a daily pill for people with type 2 diabetes while Wegovy is a 2.4 mg once-weekly injection for treating obesity. Having an additional dosing option for Ozempic will give healthcare providers and people with diabetes an additional alternative to personalize treatment based on their health goals. In addition, not all health insurance plans cover obesity treatment, so people with diabetes and excess weight or obesity may not have been able to access Wegovy with the higher dose of semaglutide. Because Ozempic is already an established diabetes medication covered by most insurance plans and Medicare, access to a higher dose may not be a problem. Novo Nordisk has said that it hopes to make the 2.0 mg dose of Ozempic available in the US in the next few months. This dosing option is also approved in Canada, Switzerland, and Europe.
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Read More »What is the best time to take Ozempic®? Administer Ozempic® once weekly on the same day each week, at any time of the day, with or without meals.
Ozempic® should be administered by a patient once weekly on the same day each week, at any time of the day, with or without meals. The day of weekly administration can be changed if necessary as long as the time between 2 doses is at least 2 days (>48 hours). If a patient misses a dose, they should administer Ozempic® as soon as possible within 5 days after the missed dose. If more than 5 days have passed, the patient should skip the missed dose, and administer the next dose on the regularly scheduled day. In each case, patients can then resume their regular once-weekly dosing schedule.
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