Do testosterone pills really work?

Testosterone supplements are often marketed as an easy way to boost testosterone levels, increase your sex drive, improve sexual performance and help with building muscle. These claims may sound impressive, but in many cases there isn't enough scientific evidence to support them.

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Testosterone supplements are often marketed as an easy way to boost testosterone levels, increase your sex drive, improve sexual performance and help with building muscle. These claims may sound impressive, but in many cases there isn’t enough scientific evidence to support them. So do testosterone supplements really work? And, if so, which ones are the most effective?

Testosterone is the main male sex hormone responsible for the development of characteristics people typically associate with masculinity, such as facial hair and a deeper voice. It’s much more than that, though. “Testosterone is important for a range of body functions,” says Dr Shaan Patel (opens in new tab), medical doctor and a medical director at Ted’s Health. “Symptoms of low testosterone range from depression and brain fog to low sperm count and decreased libido, so maintaining healthy testosterone levels is important for overall health. Hypogonadism is a condition that occurs when the body doesn’t produce enough testosterone. Many people will experience problems with testosterone levels at some point in their life. That’s when testosterone supplements come in: they either aim to replace lost testosterone or boost its production in the body. In this article, we’ll take a deep dive into the world of testosterone supplements. We’ll also look at their safety and efficacy, in order to provide a better understanding of available treatment options. However, it’s always best to consult your doctor before introducing any supplements.

What causes low testosterone levels?

It’s normal for testosterone levels to vary throughout the day. They peak early in the morning and diminish as the day goes on. Testosterone levels also fluctuate over our life span. In fact, aging is one of the biggest factors contributing to hypogonadism. As reported in the Sports Medicine (opens in new tab) journal, after the age of 40 men’s testosterone levels decline by 1%-3% per year.

Certain medical conditions and treatments can also result in hypogonadism. They include:

Injury to the testicles

Testicular cancer

Type 2 diabetes

Obesity

Klinefelter syndrome and other genetic disorders

Pituitary gland disorders, such as Cushing’s syndrome and acromegaly

Thyroid disorders

HIV

Inflammatory diseases, such as sarcoidosis or tuberculosis

Chemotherapy and other cancer treatments

Opioid medications

Diet may also play an important role in regulating testosterone. As described in the Expert Review of Endocrinology & Metabolism (opens in new tab) journal, not eating enough zinc , magnesium, vitamin D and polyphenols can disrupt the brain-testicles communication and increase the risk of hypogonadism. Chronic alcohol abuse also leads to lower testosterone levels, as described in Alcohol Research & Health (opens in new tab). Chronic psychological stress is another potential cause of low testosterone levels, as suggested by scientists from the Physiology & Behavior (opens in new tab) journal. However, they point out that not everyone may react in the same way. Individuals with poor stress management skills and unstable social relationships may experience more fluctuations in their testosterone levels.

What are testosterone supplements?

Testosterone Replacement Therapy (TRT)

TRT (or androgen replacement therapy) works by directly delivering synthetic testosterone into the body. This hormone can be injected into the buttocks, applied directly to the skin with medicated patches or administered with tablets. However, this approach is not recommended for individuals with prostate cancer , blood-clotting problems and severe cardiovascular disease .

Testosterone-boosting supplements

Testosterone supplements, or ‘testosterone boosters’, tend to be used when testosterone replacement therapy is not possible. They’re also common among athletes and bodybuilders. Testosterone supplements include the use of controlled substances like androstenedione and androstenediol, as well as over-the-counter remedies like dehydroepiandrosterone (DHEA) and D-aspartic acid (DAA). They may also contain plant extracts, herbs and other nutrients deemed to increase the production of this hormone. According to a systematic review published in the International Journal of Impotence Research (opens in new tab), common ‘testosterone-boosting’ ingredients include tribulus terrestris, eurycoma longifolia (longjack plant), zinc, L-arginine, aspartate, horny goat weed, and yohimbine.

Do testosterone supplements work?

Testosterone Replacement Therapy

According to a review published in the Therapeutics and Clinical Risk Management (opens in new tab) journal, TRT may produce a range of benefits for men with hypogonadism, including improvements in libido, sexual function, bone density, muscle mass, body composition, mood, blood cell formation, cognition, quality of life and cardiovascular disease. Many studies have also shown that TRT may help treat erectile dysfunction (opens in new tab), obesity (opens in new tab) and age-related loss of muscle strength. What’s more, testosterone treatments appear to be effective at reducing depressive symptoms, as described in the JAMA Psychiatry (opens in new tab) journal.

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Testosterone-boosting supplements

There is controversy surrounding testosterone supplements. Despite many impressive marketing claims, scientists are generally not convinced that they live up to the hype. “While there is a large body of evidence and research to show that medication prescribed by doctors to treat testosterone deficiency is effective, there are no supplements or products outside of these prescribed medications that have been clinically proven to be safe and effective,” says Patel. Dr Shaan Patel, MD, MBA Medical Doctor Dr. Shaan Patel is the Medical Director of Ted's Health and Aatma Aesthetics. He graduated with Bachelor of Medicine & Bachelor of Surgery degrees (BMBS) from the University of Southampton, U.K. Throughout his medical career he has worked across multiple disciplines, including; Vascular Surgery, Community Psychiatry, Diabetes and Endocrinology.

Nevertheless, research suggests that some of these potential ‘testosterone-boosting’ ingredients may indeed help with hypogonadism. But how effective they are may depend on the individual taking them, dosage and duration of the treatment. So, what do we know about common testosterone supplements?

Androstenedione is a weak anabolic steroid used to boost testosterone levels. According to a review published in the Molecules (opens in new tab) journal, it’s an effective testosterone supplement, but it produces side effects. As a result, it can only be provided with a doctor’s prescription. It is also listed among performance-enhancing drugs banned by the World Anti-Doping Agency, as well as the International Olympic Committee. DHEA is one of the most researched over-the-counter ingredients. According to a review published in the Experimental Gerontology (opens in new tab) journal, DHEA may help increase testosterone levels. However, the effect tends to be more significant in women than men. Also, you may need to take more than 50mg a day to get the best results. Testosterone supplements tend to combine DHEA with D-aspartic acid. As reported in the International Journal of Reproductive Biomedicine (opens in new tab), DAA performed well in studies done on animals, but did not produce similar results in humans. Another testosterone supplement is an extract from a plant called Tribulus terrestris. As stated in the Journal of Dietary Supplements (opens in new tab), some animal studies have shown that it significantly increases testosterone levels, but this effect was only noted in humans when Tribulus was part of a combined supplement. As such, there is no evidence that this ingredient can directly boost testosterone production. Certain herbs and spices may potentially act as testosterone supplements. But in many cases, the research is still in its infancy. Some studies (opens in new tab) have shown that fenugreek seed extracts, ashwagandha root extracts, Asian red ginseng and forskohlii root extracts may be beneficial. According to a review published in the Biomolecules journal, there’s a possibility that ginger extracts may also increase testosterone levels. Some vitamins and minerals are added to testosterone supplements. Indeed, many micronutrients contribute to the proper functioning of the male reproductive system. However, studies tend to produce conflicting results when it comes to testosterone levels. Zinc is an example. One study published in the Nutrition (opens in new tab) journal has shown that zinc supplementation in marginally deficient elderly men for six months resulted in almost a double increase in serum testosterone. But another study (opens in new tab) indicated that a similar approach makes no difference to testosterone levels in males who eat enough zinc. Vitamin D is another example. According to a meta-analysis published in the Endocrine (opens in new tab) journal, there’s a strong link between vitamin D deficiency and hypogonadism. At the same time, scientists from the Clinical Therapeutics (opens in new tab) journal argue that vitamin D may be important for testicular health, but there is no evidence that this nutrient can affect testosterone levels.

Are there side effects of testosterone supplements?

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Testosterone Replacement Therapy

According to a review published in the Therapeutics and Clinical Risk Management (opens in new tab) journal, TRT may worsen the symptoms of enlarged prostate, liver toxicity, blood-clotting disorders, sleep apnea and severe heart failure. People who inject testosterone may experience pain and swelling near the injection site. Topical testosterone gels and patches can also induce allergic reactions. People on TRT need to have their testosterone levels checked regularly. Otherwise, their testosterone levels may rise too high. Side effects of too much testosterone include:

Acne

Hair loss

Headaches

Aggressive behavior

Drop in sperm count

Loss of libido

Erectile dysfunction

Hypertension and heart problems

Higher red blood cell count

Enlarged prostate

Liver damage

“If you take testosterone for normal aging instead of to treat a condition, side effects may be more likely,” says Hussain Abdeh, a superintendent pharmacist at MedicineDirect (opens in new tab). “Testosterone supplements can affect the prostate and lead to an increased risk of prostate cancer.”

Testosterone-boosting supplements

Overdosing on testosterone-boosting supplements may also result in excessive testosterone levels and associated side effects. It’s especially easy with over-the-counter products, as their use is not monitored by a medical professional. What’s more, many testosterone-boosting ingredients have not been thoroughly researched and may carry unknown risks. “The potential risks of such supplementation can outweigh the benefits,” says Patel. “Many supplements are not regulated by the FDA (US Food and Drug Administration) or in the UK by MHRA (Medicines and Healthcare products Regulatory Agency). Furthermore, such supplements could even lower natural testosterone levels in the body. How? Some testosterone boosters can contain ‘prohormones’ that mimic testosterone. By doing this, your body thinks it doesn’t have to produce its own anymore.”

Can you increase your testosterone levels naturally?

Diet

Nutrition plays an indirect yet important role in regulating testosterone levels. A diet rich in fruit, vegetables, lean protein and healthy fats is the first line of defense against systemic inflammation . According to a review published in the Aging Male (opens in new tab) journal, testosterone deficiency is closely linked to an increased production of pro-inflammatory signaling proteins. Eating too much, or not enough, of certain macronutrients may also affect your testosterone levels. Data (opens in new tab) from health surveys have shown that consumption of sugar-sweetened beverages is a significant contributor to hypogonadism in young, adult men.

Weight loss

According to a review in Obesity Reviews (opens in new tab), testosterone is a key hormone in the development of obesity and metabolic diseases, such as insulin resistance and dyslipidemia. Similarly, excess weight can lead to lower testosterone levels. “Obesity is directly linked to low testosterone,” says Patel. “A four inch increase in waist size can increase your chances of having low testosterone by up to 75%.”

Exercise

Evidence is growing that certain types of physical activity can temporarily increase testosterone levels. According to a meta-analysis published in the Journal of Endocrinological Investigation (opens in new tab), strenuous exercise and resistance training can particularly help with testosterone production. At the same time, scientists from the Journal of Strength and Conditioning Research (opens in new tab) argue that this approach may not work for men who do not suffer from hypogonadism.

Sleep

A good night’s sleep may help to prevent low testosterone levels. According to a meta-analysis published in the Sleep Medicine (opens in new tab) journal, sleep deprivation lasting more than 24 hours may be particularly harmful. This article is for informational purposes only and is not meant to offer medical advice.

livescience.com - Do testosterone supplements really work? - Live Science

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