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Do people keep weight off after Ozempic?

Recent research published in the journal Diabetes, Obesity and Metabolism indicates that once patients stop using semaglutide drugs like Wegovy and Ozempic any weight they've lost is likely to return.

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Share on Pinterest Taking semaglutide medication like Wegovy and Ozempic can help people lose weight, but they often regain lost pounds once they stop. Sergey Mironov/Getty Images Research has found that when people stop using semaglutide, weight rebound occurs. Experts say this is because the drug is not a cure and it does not prevent the metabolic adaptation that occurs during weight loss. Long-term changes in diet and activity are an important part of maintaining weight loss. It is also important to consult with a physician before using weight loss medications. Recent research published in the journal Diabetes, Obesity and Metabolism indicates that once patients stop using semaglutide drugs like Wegovy and Ozempic any weight they’ve lost is likely to return. According to Dr. Ibiye Owei, Assistant Professor at Texas Tech University Health Sciences Center El Paso, semaglutide is a glucagon-like-peptide-1 agonist (GLP-1 agonist) which has been approved by the Food and Drug Administration (FDA) to treat diabetes and obesity or overweight. “It works by making people feel full sooner and suppressing the appetite so people do not feel as hungry,” she explained. “One of the ways it does this is by slowing emptying of the stomach so there is a feeling of satiety.” Owei added that anyone with obesity defined as a Body Mass Index (BMI) of 30 and above or a BMI of 27 and above who is experiencing weight-related complications such as hypertension or type 2 diabetes would be a good candidate to use this medication. Semaglutide is one of the most effective treatments for obesity According to Dr. Kathleen Dungan, an endocrinologist in the Division of Endocrinology, Diabetes & Metabolism at The Ohio State University Wexner Medical Center, there are several potential benefits to using semaglutide. “It is one of the most effective treatments available for either condition, outside of bariatric surgery,” said Dungan. “Moreover, there is evidence that the use of semaglutide may reduce the risk for developing diabetes and may be particularly useful in individuals who have prediabetes.” What happens when you quit taking semaglutide While drugs like Wegovy and Ozempic might seem like a miracle to those with diabetes and obesity, the truth is the effects only last while you are taking the medication. A study published in April 2022 which sought to examine changes in body weight and cardiometabolic risk factors upon the termination of the drug, found that after a year people had regained two-thirds of the weight they had lost. The positive changes they had seen in cardiometabolic risk factors like blood pressure, blood lipids, HbA1c, and C-reactive protein had similarly reversed. According to the study authors, these findings reinforce the need to continue treatment in order to maintain the benefits of the medication. Why rebound weight gain occurs According to Dungan, weight rebound occurs quite simply because the drug does not cure the underlying issues that led to weight gain in the first place. Owei further explained that metabolic adaptation occurs while patients are losing weight and this can contribute to weight gain when the medication is ended. She said that this effect isn’t unique to semaglutide. “This happens regardless of what weight loss method is employed,” she said, pointing out a study showing that contestants of the TV show “The Biggest Loser” had experienced a decrease in resting metabolic rate that still persisted 6 years after the competition had ended.

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How does this new diabetes medication work? Teplizumab is a monoclonal antibody that modifies T cells in a way that prolongs the pancreas' ability to create insulin. The drug is specific to a molecule called CD3, which is the “cognate” component of the T cell, Dr.

The Food and Drug Administration (FDA) recently approved a medication that can delay the onset of type 1 diabetes. This marks the first treatment to change the course of this autoimmune disease since the discovery of insulin in 1922. Type 1 diabetes, also known as type 1 diabetes mellitus, is a chronic disorder characterized by high levels of glucose in the blood due to the pancreas making little to no insulin—a hormone needed for glucose to enter the body's cells and for survival. Each year, around 30,000 Americans (of all ages) receive a diagnosis of type 1 diabetes. It is one of the most common chronic diseases of childhood, impacting between 1 in 300 to 1 in 600 school-aged children. Type 1 diabetes is a lifelong condition that requires constant insulin therapy and diet management. Researchers say the drug postpones the median onset of the disease by at least two years. The medication is delivered through a daily infusion for two weeks. Kevan Herold, MD, a Yale Medicine endocrinologist, was the principal investigator of the new medication, called teplizumab, made by Provention Bio. Provention will partner with Sanofi to market the drug in the U.S. and sell it under the brand name Tzield. We talked with Dr. Herold, who answered three important questions about the drug and the future of diabetes management.

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