Can Ozempic cause bowel problems?

Keep in mind that Ozempic can cause other digestive side effects such as diarrhea, flatulence (gas), and constipation. These other side effects may contribute to stomach pain. Severe abdominal pain with Ozempic can be a symptom of pancreatitis, a less common but serious side effect of the drug.

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Ozempic has a boxed warning for the risk of thyroid tumors. This is a serious warning from the Food and Drug Administration (FDA). For details, see the “ Ozempic: Side effects explained” section below. Ozempic: Introduction Ozempic is a brand-name prescription drug. It’s a type of drug called a glucagon-like peptide 1 (GLP-1) receptor agonist, and it contains the active drug semaglutide. It comes as a solution in prefilled pens and is given by subcutaneous injection. Ozempic is typically used long term. It is approved by the Food and Drug Administration (FDA) to: improve blood sugar levels when used in combination with diet and exercise in adults with type 2 diabetes lower the risk for serious heart problems such as heart attack, stroke, and heart-related death in adults with both type 2 diabetes and cardiovascular disease Similar to other drugs, Ozempic may cause side effects. Read below for information about possible side effects, including common, mild, and serious ones. For a general overview of Ozempic, including details about its uses, see this article. If you’d like to take Ozempic, search here to find a healthcare professional who might prescribe it. Ozempic: More common side effects Some of Ozempic’s side effects may be more common than others. These side effects may last only a few days to weeks. However, some side effects may last longer or become severe or bothersome. Tell your doctor or pharmacist if you have concerns about any side effects with Ozempic. In Ozempic’s clinical studies, these were some side effects that occurred more often: abdominal pain*

nausea and vomiting*

constipation*

diarrhea * For more information about this side effect, see “Ozempic: Side effects explained” below. Ozempic: Mild side effects Ozempic can cause mild side effects, which are listed below. However, this list doesn’t include all possible mild side effects. To learn more about Ozempic’s side effects, view the drug’s prescribing information. Ozempic’s mild side effects include: diarrhea

belching

flatulence (gas)

fatigue

dizziness

changes in taste

acid reflux

discomfort or redness at injection site

gastritis (irritation of the stomach lining)

constipation*

abdominal pain*

nausea and vomiting* The side effects listed above may last only a few days to weeks. However, some side effects may last longer or become severe or bothersome. Tell your doctor or pharmacist if you have concerns about side effects with Ozempic. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you develop a side effect while taking Ozempic and want to tell the FDA about it, visit MedWatch. * For more information about this side effect, see “Ozempic: Side effects explained” below. Ozempic: Side effects explained Here’s detailed information about some of Ozempic’s side effects. Risk of thyroid tumors Ozempic has a boxed warning regarding the risk of thyroid tumors. A boxed warning is the strongest warning required by the Food and Drug Administration (FDA). These warnings alert doctors and patients about drug effects that may be dangerous. Animals given Ozempic had an increased risk of thyroid tumors in clinical studies. There have also been reports of thyroid cancer with the use of other medications in the same drug class as Ozempic. It’s not clear whether Ozempic causes thyroid tumors in humans. Due to this possible risk, Ozempic should not be used if you have a personal or family history of certain types of thyroid cancer. Symptoms of thyroid tumors include: difficulty breathing

trouble swallowing

a lump in your neck

hoarse voice What to do Talk with your doctor about your risk of developing thyroid tumors. Before starting Ozempic, tell your doctor if you or your family have a history of medullary thyroid carcinoma (MTC) or a rare genetic (inherited) condition called multiple endocrine neoplasia syndrome type 2 (MEN 2). Having MEN 2 increases your risk of thyroid tumors. Also, if you have symptoms of a thyroid tumor while taking Ozempic, tell your doctor right away. Nausea and vomiting The most common side effect of Ozempic in clinical studies was nausea. Vomiting was also a common side effect. However, vomiting happened less often than nausea. Both side effects happened more often in people whose dosage of Ozempic was higher or recently increased. See Ozempic’s prescribing information to learn how often these side effects occurred during clinical studies. What to do If you have nausea or vomiting with Ozempic, talk with your doctor. They may advise that you eat a bland diet that doesn’t contain greasy or sugary foods. They may also recommend that you slowly drink liquids such as water, ginger drinks, or peppermint tea to help prevent dehydration and ease nausea. Your nausea and vomiting may lessen or go away with time. However, if these side effects become bothersome, talk with your doctor. Constipation Constipation was a common side effect of Ozempic in clinical studies. Symptoms of constipation include: bloating or swelling in your abdomen

cramping or pain in your abdomen

passing hard or lumpy stools

straining to have a bowel movement See Ozempic’s prescribing information to learn how often this side effect occurred in clinical studies. What to do If you have constipation with Ozempic, talk with your doctor. They can advise ways to help relieve your symptoms without medication. This can include drinking plenty of water and increasing fiber-containing foods in your diet. They may also advise that you avoid skipping meals and consuming processed foods. Talk with your doctor if your constipation does not ease while taking Ozempic. Abdominal pain Abdominal pain was a commonly reported side effect of Ozempic in clinical studies. This type of pain can be sharp, dull, or intermittent. It can also feel like cramps or aches. Keep in mind that Ozempic can cause other digestive side effects such as diarrhea, flatulence (gas), and constipation. These other side effects may contribute to stomach pain. Severe abdominal pain with Ozempic can be a symptom of pancreatitis, a less common but serious side effect of the drug. (With pancreatitis, the pancreas is inflamed.) Tell your doctor right away if you have stomach pain that spreads to your back. Also let them know if you have this side effect in combination with vomiting. These can be signs of pancreatitis. See Ozempic’s prescribing information to learn how often this side effect occurred during clinical studies. What to do If your symptoms are mild, talk with your doctor. To help ease your abdominal pain, they may recommend that you: use a heating pad

take a warm bath

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drink chamomile or peppermint tea

drink plenty of water or clear liquids However, tell your doctor if your pain doesn’t go away or becomes severe and spreads to your back. Also let your doctor know if you have vomiting. These symptoms could be signs of pancreatitis. Diabetic retinopathy Diabetic retinopathy is an eye disease that occurs in people with diabetes. This condition damages the small blood vessels in the eyes. Symptoms of diabetic retinopathy can include: vision changes

vision loss

poor night vision In clinical studies, diabetic retinopathy occurred in some people taking Ozempic. The risk for complications from the condition was increased in people who’d already had diabetic retinopathy in the past. Possible complications of diabetic retinopathy include eye bleeding and glaucoma. (With glaucoma, fluid builds up in the eye and leads to problems such as vision loss.) The effect of long-term use of Ozempic on diabetic retinopathy complications is unknown. See Ozempic’s prescribing information to learn how often this side effect occurred during clinical studies. What to do Tell your doctor right away if you develop symptoms of diabetic retinopathy. Also, if you have a history of diabetic retinopathy, tell your doctor. They may monitor you more closely than usual during treatment with this drug. Allergic reaction As with most drugs, some people can have an allergic reaction after taking Ozempic. A more severe allergic reaction is rare but possible. Allergic reaction wasn’t reported in clinical studies of Ozempic. However, this side effect has been reported since the drug became available for use. Possible symptoms of mild and serious allergic reactions are listed in the table below. Mild allergic reaction symptoms Serious allergic reaction symptoms • itching • trouble breathing • rash • swelling in your throat or mouth • flushing • swelling under your skin, possibly in your hands, feet, lips, or eyelids If you have an allergic reaction to Ozempic, call your doctor right away. This is important to do because the reaction could become severe. However, if you’re having a medical emergency or your symptoms feel life threatening, call 911 or a local emergency number. Ozempic: Weight loss As Ozempic can decrease appetite, weight loss may occur with use of the drug. However, weight loss is not an approved use of Ozempic. Another medication with the same active drug is approved for use in certain adults to help manage weight. This medication, called Wegovy, is prescribed in combination with diet and exercise for long-term weight management. Both Ozempic and Wegovy contain the active drug semaglutide. If you’re concerned about changes in your weight with Ozempic, talk with your doctor. If you’d like to learn about medications used for weight management, let your doctor know. Ozempic: Common questions about side effects Here are some common questions about the drug’s side effects and answers to them. Talk with your doctor if you have other questions about this drug. Is headache a side effect of Ozempic? No, Ozempic isn’t likely to cause headaches. Headache wasn’t reported as a side effect in clinical studies of Ozempic. However, headache is a symptom of hypoglycemia (low blood sugar). And hypoglycemia is a side effect of Ozempic. If you experience headaches with Ozempic, talk with your doctor. They can help determine the cause of this symptom and advise on ways to relieve your headaches. They can also recommend ways to prevent hypoglycemia. Other drugs for type 2 diabetes can increase your risk of hypoglycemia. Examples include insulin or medications that cause your body to produce more insulin, such as insulin secretagogues. You may have a headache from low blood sugar if you’re taking these other diabetes drugs with Ozempic. For more information about symptoms of hypoglycemia, see “Ozempic: Serious side effects” above. Does Ozempic cause hair loss? No, hair loss was not reported as a side effect of Ozempic in clinical studies. However, there have been cases of hair loss in people with type 1 and type 2 diabetes. Keep in mind that Ozempic is used to treat type 2 diabetes. If you experience hair loss with Ozempic, it may be due to your condition, not the medication itself. Talk with your doctor if you have concerns about hair loss. Can I have injection-related side effects from using Ozempic pens? Yes, injection-related side effects were reported in clinical studies of Ozempic. These symptoms included redness and discomfort at the site where Ozempic was injected. However, these side effects were not common. Injection-related side effects should not last long. If the discomfort or discoloration does not go away or worsens, talk with your doctor. Ozempic comes as a solution in prefilled pens. It’s administered as a subcutaneous injection in the thigh, abdomen, or upper arm. If you’re injecting Ozempic in the same area of the body, inject the doses into different sites to help prevent skin problems. If you experience bothersome injection-related side effects with Ozempic, talk with your doctor. Ozempic: Precautions Ozempic comes with several precautions. Boxed warning: Risk of thyroid tumors Ozempic has a boxed warning for the risk of thyroid tumors. This is a serious warning from the Food and Drug Administration (FDA). For details, see the “Ozempic: Side effects explained” section above. Other precautions Be sure to talk with your doctor about your health history before taking Ozempic. This drug may not be the right treatment option if you have certain medical conditions or other factors that affect your health. The conditions and factors to consider include those described below. Kidney problems. Medications in the same drug class as Ozempic have caused sudden, severe kidney injury and worsening chronic kidney failure. Many of these cases occurred in people who also had nausea, vomiting, diarrhea, or dehydration. Tell your doctor if you experience these symptoms with Ozempic. They may be signs of a kidney problem. Also let your doctor know if you have or have had kidney problems in the past. They may monitor you more closely than usual or prescribe a different treatment for your condition. Pancreatitis. Pancreatitis (inflammation of the pancreas) can occur with Ozempic. Talk with your doctor if you’ve had pancreatitis. They may recommend a different treatment option for you. If you think you have pancreatitis, stop taking Ozempic and call your doctor right away. If your doctor determines that you have pancreatitis, they will have you stop Ozempic and they’ll recommend another treatment. Taking certain other diabetes drugs. There’s an increased risk of hypoglycemia (low blood sugar) if Ozempic is taken with certain other diabetes medications. Tell your doctor about any other diabetes drugs you may take. They may lower the dose of your other diabetes medications to help reduce your risk of hypoglycemia with Ozempic. For more details on hypoglycemia, see the “Ozempic: Serious side effects” section above. Allergic reaction. If you’ve had an allergic reaction to Ozempic or any of its ingredients, your doctor will likely not prescribe Ozempic. Ask your doctor which other medications may be better options for you. Diabetic retinopathy. Tell your doctor if you have diabetic retinopathy (a diabetes-related eye condition). Ozempic may worsen it. If you have diabetic retinopathy, your doctor may monitor you more closely than usual while you are taking Ozempic. Tell your doctor if you have any vision changes during your Ozempic treatment. Consuming alcohol during Ozempic treatment It’s not known whether it’s safe to drink alcohol while taking Ozempic. Ozempic lowers blood sugar, as does alcohol. For this reason, there is an increased risk of hypoglycemia (low blood sugar) if Ozempic and alcohol are used together. In addition, long-term alcohol use can cause pancreatitis (swelling of the pancreas). Pancreatitis is also a serious side effect of Ozempic. If you drink alcohol, talk with your doctor about a safe amount to drink while taking Ozempic. Pregnancy and breastfeeding during Ozempic treatment Read below for information on taking Ozempic while pregnant or breastfeeding. Pregnancy. It’s unknown whether it is safe to use Ozempic during pregnancy or while breastfeeding. Your doctor will likely recommend you do not take Ozempic while you’re pregnant. The drug’s manufacturer recommends stopping Ozempic 2 months before you plan to become pregnant. However, don’t stop taking your medication or change your dose without first talking with your doctor. If you plan to become pregnant, talk with your doctor about treatment options to manage your blood sugar while pregnant. If you become pregnant while taking Ozempic, tell your doctor right away. Breastfeeding. It’s unknown whether Ozempic can pass into breast milk. Your doctor will likely recommend you do not take Ozempic while you’re breastfeeding. Talk with your doctor about how to safely feed your child while being treated with Ozempic.

healthgrades.com - Ozempic: Side Effects and How to Manage Them - Healthgrades

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