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Can I take L-carnitine daily?

L-carnitine has most often been used by adults in doses of 2 grams by mouth daily. In children, L-carnitine has most often been used in doses of 50-100 mg/kg by mouth daily, for up to one year. Speak with a healthcare provider to find out what dose might be best for a specific condition.

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G., Melis, A., Piga, M., Marchionni, A., and Calvani, M. Influence of acetyl-carnitine on some mitochondrial enzymic activities in the human cerebral tissue in conditions of acute hypoxia. Int J Tissue React. 1992;14(4):183-194. View abstract. Corbucci, G. G., Menichetti, A., Cogliatti, A., Nicoli, P., and Ruvolo, C. Metabolic aspects of acute tissue hypoxia during extracorporeal circulation and their modification induced by L-carnitine treatment. Int J Clin Pharmacol Res 1992;12(3):149-157. View abstract. Corsi, C., Pollastri, M., Marrapodi, E., Leanza, D., Giordano, S., and D'Iddio, S. L-propionylcarnitine effect on postexercise and postischemic hyperemia in patients affected by peripheral vascular disease. Angiology 1995;46(8):705-713. View abstract. Costa, M., Canale, D., Filicori, M., D'lddio, S., and Lenzi, A. L-carnitine in idiopathic asthenozoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia 1994;26(3):155-159. View abstract. Coto V, D'Alessandro L, Grattarola G, and et al. Evaluation of the therapeutic efficacy and tolerability of levocarnitine propionyl in the treatment of chronic obstructive arteriopathies of the lower extremities: a multicentre controlled study vs. placebo. Drugs Exptl Clin Res 1992;18(1):29-36. Crentsil, V. Mechanistic contribution of carnitine deficiency to geriatric frailty. Ageing Res.Rev. 2010;9(3):265-268. View abstract. Crill, C. M., Christensen, M. L., Storm, M. C., and Helms, R. A. Relative bioavailability of carnitine supplementation in premature neonates. JPEN J Parenter.Enteral Nutr. 2006;30(5):421-425. View abstract. Crill, C. M., Storm, M. C., Christensen, M. L., Hankins, C. T., Bruce, Jenkins M., and Helms, R. A. Carnitine supplementation in premature neonates: effect on plasma and red blood cell total carnitine concentrations, nutrition parameters and morbidity. Clin Nutr. 2006;25(6):886-896. View abstract. Cruciani, R. A., Dvorkin, E., Homel, P., Culliney, B., Malamud, S., Lapin, J., Portenoy, R. K., and Esteban-Cruciani, N. L-carnitine supplementation in patients with advanced cancer and carnitine deficiency: a double-blind, placebo-controlled study. J Pain Symptom.Manage. 2009;37(4):622-631. View abstract. Cruciani, R. A., Dvorkin, E., Homel, P., Culliney, B., Malamud, S., Shaiova, L., Fleishman, S., Lapin, J., Klein, E., Lesage, P., Portenoy, R., and Esteban-Cruciani, N. L-carnitine supplementation for the treatment of fatigue and depressed mood in cancer patients with carnitine deficiency: a preliminary analysis. Ann N.Y.Acad.Sci 2004;1033:168-176. View abstract. Csiky, B., Nyul, Z., Toth, G., Wittmann, I., Melegh, B., Rauh, M., Rascher, W., and Sulyok, E. L-carnitine supplementation and adipokines in patients with end-stage renal disease on regular hemodialysis. Exp.Clin Endocrinol.Diabetes 2010;118(10):735-740. View abstract. Cucinotta D, Passeri M, Ventura S, and et al. 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Dal Negro, R., Turco, P., Pomari, C., and De Conti, F. Effects of L-carnitine on physical performance in chronic respiratory insufficiency. Int J Clin Pharmacol Ther Toxicol. 1988;26(5):269-272. View abstract. de Lira-Garcia, C., Souto-Gallardo, M., Bacardi-Gascon, M., and Jimenez-Cruz, A. [A systematic review of the effectiveness of alternative weight-loss products' ingredients]. Rev.Salud Publica (Bogota.) 2008;10(5):818-830. View abstract. De Marchi, S., Zecchetto, S., Rigoni, A., Prior, M., Fondrieschi, L., Scuro, A., Rulfo, F., and Arosio, E. Propionyl-L-carnitine improves endothelial function, microcirculation and pain management in critical limb ischemia. Cardiovasc.Drugs Ther 2012;26(5):401-408. View abstract. De Pasquale, B., Righetti, G., and Menotti, A. [L-carnitine for the treatment of acute myocardial infarct]. Cardiologia 1990;35(7):591-596. View abstract. De Ritis G, Picardo S, Brancadoro D, and et al. The effect of carnitine in patients using artificial pacemakers. Current Therapeutic Research 1989;46(6):1027-1033. De Simone C, Catania S, Trinchieri V, and et al. Amelioration of the depression of HIV-infected subjects with L-acetyl carnitine therapy. J Drug Dev 1988;1(3):163-166. De Simone, C., Tzantzoglou, S., Famularo, G., Moretti, S., Paoletti, F., Vullo, V., and Delia, S. High dose L-carnitine improves immunologic and metabolic parameters in AIDS patients. Immunopharmacol.Immunotoxicol. 1993;15(1):1-12. View abstract. De Vecchi, A. F., Arduini, A., Di, Liberato L., and Bonomini, M. [L-carnitine in peritoneal dialysis]. G.Ital.Nefrol. 2011;28(4):393-400. View abstract. Dealberto, M. J. Valproate-induced hyperammonaemic encephalopathy: review of 14 cases in the psychiatric setting. Int.Clin Psychopharmacol. 2007;22(6):330-337. View abstract. Decombaz, J., Deriaz, O., Acheson, K., Gmuender, B., and Jequier, E. Effect of L-carnitine on submaximal exercise metabolism after depletion of muscle glycogen. Med Sci Sports Exerc. 1993;25(6):733-740. View abstract. DeFelice SL and Gilgore SG. The antagonistic effect of carnitine in hyperthyroidism. Preliminary report. Journal of New Drugs 1966;6(6):351-353. del Olmo, J. A., Castillo, M., Rodrigo, J. M., Aparisi, L., Serra, M. A., Wassel, A., and Bixquert, M. Effect of L-carnitine upon ammonia tolerance test in cirrhotic patients. Adv Exp Med Biol 1990;272:197-208. View abstract. Demeyere, R., Lormans, P., Weidler, B., Minten, J., Van Aken, H., and Flameng, W. Cardioprotective effects of carnitine in extensive aortocoronary bypass grafting: a double-blind, randomized, placebo-controlled clinical trial. Anesth.Analg. 1990;71(5):520-528. View abstract. Derosa, G., Cicero, A. F., Gaddi, A., Mugellini, A., Ciccarelli, L., and Fogari, R. The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Clin Ther 2003;25(5):1429-1439. View abstract. Derosa, G., Maffioli, P., Ferrari, I., D'Angelo, A., Fogari, E., Palumbo, I., Randazzo, S., and Cicero, A. F. Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patients. Fundam.Clin Pharmacol 2011;25(5):642-651. View abstract. Derosa, G., Maffioli, P., Ferrari, I., D'Angelo, A., Fogari, E., Palumbo, I., Randazzo, S., and Cicero, A. F. Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients. Endocr.J 2010;57(9):777-786. View abstract. Derosa, G., Maffioli, P., Salvadeo, S. A., Ferrari, I., Gravina, A., Mereu, R., D'Angelo, A., Palumbo, I., Randazzo, S., and Cicero, A. F. Effects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patients. Metabolism 2011;60(3):421-429. View abstract. Derosa, G., Maffioli, P., Salvadeo, S. A., Ferrari, I., Gravina, A., Mereu, R., D'Angelo, A., Palumbo, I., Randazzo, S., and Cicero, A. F. Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients. Intern.Med 2010;49(16):1717-1725. View abstract. Desbree, A., Houdon, L., Touati, G., Djemili, S., Choker, G., and Flodrops, H. [EBV infection revealing a long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency in a 3-year-old boy]. Arch.Pediatr. 2011;18(1):18-22. View abstract. Digiesi, V., Palchetti, R., and Cantini, F. [The benefits of L-carnitine therapy in essential arterial hypertension with diabetes mellitus type II]. Minerva Med 1989;80(3):227-231. View abstract. DiMauro, S. and Hirano, M. Mitochondrial DNA Deletion Syndromes. In: Pagon, R. A., Bird, T. D., Dolan, C. R., Stephens, K., and Adam, M. P. GeneReviews [Internet]. Seattle, WA: University of Washington, Seattle;1993. View abstract. Dimitriadis, F., Tsambalas, S., Tsounapi, P., Kawamura, H., Vlachopoulou, E., Haliasos, N., Gratsias, S., Watanabe, T., Saito, M., Miyagawa, I., and Sofikitis, N. Effects of phosphodiesterase-5 inhibitors on Leydig cell secretory function in oligoasthenospermic infertile men: a randomized trial. BJU.Int. 2010;106(8):1181-1185. View abstract. DiNicolantonio, J. J., Lavie, C. J., Fares, H., Menezes, A. R., and O'Keefe, J. H. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis. Mayo Clin Proc. 2013;88(6):544-551. View abstract. Dokmeci, D., Inan, M., Basaran, U. N., Yalcin, O., Aydogdu, N., Turan, F. N., and Uz, Y. H. Protective effect of L-carnitine on testicular ischaemia-reperfusion injury in rats. Cell Biochem.Funct. 2007;25(6):611-618. View abstract. Donnelly, C. T., Hameed, A. B., Abdenur, J. E., and Wing, D. A. Carnitine deficiency in pregnancy. Obstet.Gynecol. 2007;110(2 Pt 2):480-482. View abstract. Dragan, A. M., Vasiliu, D., Eremia, N. M., and Georgescu, E. Studies concerning some acute biological changes after endovenous administration of 1 g l-carnitine, in elite athletes. Physiologie. 1987;24(4):231-234. View abstract.

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Dragan, G. I., Vasiliu, A., Georgescu, E., and Dumas, I. Studies concerning chronic and acute effects of L-carnitine on some biological parameters in elite athletes. Physiologie. 1987;24(1):23-28. View abstract. Dragan, I. G., Vasiliu, A., Georgescu, E., and Eremia, N. Studies concerning chronic and acute effects of L-carnitina in elite athletes. Physiologie. 1989;26(2):111-129. View abstract. Duranay, M., Akay, H., Yilmaz, F. M., Senes, M., Tekeli, N., and Yucel, D. Effects of L-carnitine infusions on inflammatory and nutritional markers in haemodialysis patients. Nephrol.Dial Transplant 2006;21(11):3211-3214. View abstract. Dutta, A., Ray, K., Singh, V. K., Vats, P., Singh, S. N., and Singh, S. B. L-carnitine supplementation attenuates intermittent hypoxia-induced oxidative stress and delays muscle fatigue in rats. Exp.Physiol 2008;93(10):1139-1146. View abstract. Eidi, M., Pouyan, O., Shahmohammadi, P., Saeidi, H., Bahar, M., and Eidi, A. Effect of L-carnitine supplement on semen parameters in men with idiopathic infertility. J.Med.Sci.J.Islamic Azad Univ. 2009;19(1):Pe11-Pe15. El Beshlawy, A., Abd, El Raouf, Mostafa, F., Talaat, M., Isma'eel, H., Aoun, E., Hoffbrand, A. V., and Taher, A. Diastolic dysfunction and pulmonary hypertension in sickle cell anemia: is there a role for L-carnitine treatment? Acta Haematol. 2006;115(1-2):91-96. View abstract. El Beshlawy, A., Mohtar, G., Abd El, Ghafar E., Abd El Dayem, S. M., El Sayed, M. H., Aly, A. A., and Farok, M. Assessment of puberty in relation to L-carnitine and hormonal replacement therapy in beta-thalassemic patients. J Trop.Pediatr. 2008;54(6):375-381. View abstract. El-Beshlawy, A., El, Accaoui R., Abd El-Sattar, M., Gamal El-Deen, M. H., Youssry, I., Shaheen, N., Hamdy, M., El-Ghamrawy, M., and Taher, A. Effect of L-carnitine on the physical fitness of thalassemic patients. Ann.Hematol. 2007;86(1):31-34. View abstract. El-Beshlawy, A., Youssry, I., El-Saidi, S., El, Accaoui R., Mansi, Y., Makhlouf, A., and Taher, A. Pulmonary hypertension in beta-thalassemia major and the role of L-carnitine therapy. Pediatr.Hematol.Oncol. 2008;25(8):734-743. View abstract. El-Metwally, T. H., Hamed, E. A., Ahmad, A. R., and Mohamed, N. A. Dyslipidemia, oxidative stress and cardiac dysfunction in children with chronic renal failure: effects of L-carnitine supplementation. Ann.Saudi.Med. 2003;23(5):270-277. View abstract. Ellaway, C. J., Peat, J., Williams, K., Leonard, H., and Christodoulou, J. Medium-term open label trial of L-carnitine in Rett syndrome. Brain Dev. 2001;23 Suppl 1:S85-S89. View abstract. Elmslie, J. L., Porter, R. J., Joyce, P. R., Hunt, P. J., and Mann, J. I. Carnitine does not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet. Bipolar.Disord. 2006;8(5 Pt 1):503-507. View abstract. Erbas, H., Aydogdu, N., Usta, U., and Erten, O. Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide. Cell Biol.Int. 2007;31(11):1414-1419. View abstract. Eroglu, H., Senel, O., and Guzel, N. A. Effects of acute L-carnitine intake on metabolic and blood lactate levels of elite badminton players. Neuro.Endocrinol.Lett. 2008;29(2):261-266. View abstract. Evangelista, M., Koverech, A., Messano, M., and Pescosolido, N. Comparison of three lubricant eye drop solutions in dry eye patients. Optom.Vis.Sci 2011;88(12):1439-1444. View abstract. Evans, J. D., Jacobs, T. F., and Evans, E. W. Role of acetyl-L-carnitine in the treatment of diabetic peripheral neuropathy. Ann.Pharmacother. 2008;42(11):1686-1691. View abstract. Fagher, B., Cederblad, G., Eriksson, M., Monti, M., Moritz, U., Nilsson-Ehle, P., and Thysell, H. L-carnitine and haemodialysis: double blind study on muscle function and metabolism and peripheral nerve function. Scand.J Clin Lab Invest 1985;45(2):169-178. View abstract. Fagher, B., Cederblad, G., Monti, M., Olsson, L., Rasmussen, B., and Thysell, H. Carnitine and left ventricular function in haemodialysis patients. Scand.J Clin Lab Invest 1985;45(3):193-198. View abstract. Fagher, B., Thysell, H., Nilsson-Ehle, P., Monti, M., Olsson, L., Eriksson, M., Lindstedt, S., and Lindholm, T. The effect of D,L-carnitine supplementation on muscle metabolism, neuropathy, cardiac and hepatic function in hemodialysis patients. A pilot study. Acta Med Scand 1982;212(3):115-120. View abstract. Famularo, G., Moretti, S., Alesse, E., Trinchieri, V., Angelucci, A., Santini, G., Cifone, G., and De, Simone C. Reduction of glutamate levels in HIV-infected subjects treated with acetylcarnitine. J NeuroAIDS. 1999;2(2):65-73. View abstract. Fan, J. P., Kim, H. S., and Han, G. D. Induction of apoptosis by L-carnitine through regulation of two main pathways in Hepa1c1c 7 cells. Amino.Acids 2009;36(2):365-372. View abstract. Faria, C. C., Mota, J. F., Paula Ravagnani, F. 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Feinfeld, D. A., Kurian, P., Cheng, J. T., Dilimetin, G., Arriola, M. R., Ward, L., Manis, T., and Carvounis, C. P. Effect of oral L-carnitine on serum myoglobin in hemodialysis patients. Ren Fail. 1996;18(1):91-96. View abstract. Fenkci, S. M., Fenkci, V., Oztekin, O., Rota, S., and Karagenc, N. Serum total L-carnitine levels in non-obese women with polycystic ovary syndrome. Hum.Reprod. 2008;23(7):1602-1606. View abstract. Fernandez, C. and Proto, C. [L-carnitine in the treatment of chronic myocardial ischemia. An analysis of 3 multicenter studies and a bibliographic review]. Clin Ter. 1992;140(4):353-377. View abstract. Ferrari R, Cucchini F, Dilisa F, and et al. The effect of L-carnitine (carnitene) on myocardial metabolism of patients with coronary artery disease. Clin Trial J 1984;21:40-58. Fietta, P. and Manganelli, P. Carnitine: a therapeutic option for childhood psoriatic onycho-pachydermo-periostitis (POPP). Clin Rheumatol. 2007;26(1):93-94. View abstract. Filipek, P. A., Juranek, J., Nguyen, M. T., Cummings, C., and Gargus, J. J. Relative carnitine deficiency in autism. J Autism Dev.Disord. 2004;34(6):615-623. View abstract. Foitzik, K., Hoting, E., Heinrich, U., Tronnier, H., and Paus, R. Indications that topical L-carnitin-L-tartrate promotes human hair growth in vivo. J Dermatol.Sci 2007;48(2):141-144. View abstract. Footitt, E. J., Stafford, J., Dixon, M., Burch, M., Jakobs, C., Salomons, G. S., and Cleary, M. A. Use of a long-chain triglyceride-restricted/medium-chain triglyceride-supplemented diet in a case of malonyl-CoA decarboxylase deficiency with cardiomyopathy. J Inherit.Metab Dis 6-15-2010; View abstract. Fornasini, G., Upton, R. N., and Evans, A. M. A pharmacokinetic model for L-carnitine in patients receiving haemodialysis. Br.J Clin Pharmacol 2007;64(3):335-345. View abstract. Fortin, G., Yurchenko, K., Collette, C., Rubio, M., Villani, A. C., Bitton, A., Sarfati, M., and Franchimont, D. L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation. Clin Exp.Immunol. 2009;156(1):161-171. View abstract. Fujiwara, M., Nakano, T., Tamoto, S., Yamada, Y., Fukai, M., Takada, K., Ashida, H., Shimada, T., Ishihara, T., and Seki, I. [Effect of L-carnitine in patients with ischemic heart disease]. J Cardiol 1991;21(2):493-504. View abstract. Fulgente T, Onofrj M Del Re ML et al. Laevo-acetylcarnitine (Nicetile registered) treatment of senile depression. Clin Trials J 1990;27:155-163. Galvano, F., Li, Volti G., Malaguarnera, M., Avitabile, T., Antic, T., Vacante, M., and Malaguarnera, M. Effects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitus. Expert.Opin.Pharmacother. 2009;10(12):1875-1882. View abstract. Ganio, M. S., Klau, J. F., Lee, E. C., Yeargin, S. W., McDermott, B. P., Buyckx, M., Maresh, C. M., and Armstrong, L. E. 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How fast can you lose 100 pounds safely? It's important to note that losing 100 pounds will likely take at least 6 months to a year or longer. Most...

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Spasov, A. A., Iezhitsa, I. N., Kravchenko, M. S.,

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