Tropical Weight Loss
Tropical Weight Loss
Photo: Breno Cardoso
The researchers found that people who lost the most weight while taking semaglutide tended to then regain the most after stopping it, although they still retained a larger reduction from baseline than participants who had lost less weight during the treatment period.
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Read More »medwireNews: People who lose weight while taking semaglutide 2.4 mg regain two-thirds of what they lost during the first year after stopping the medication, shows the STEP 1 extension study. John Wilding (University of Liverpool, UK) and co-researchers say this is in line with studies of other weight loss medications, which also showed weight regain after withdrawal. “Taken together, these findings and those of the present study confirm the chronicity of obesity and highlight the importance of maintaining long-term pharmacological treatment for weight management in people with obesity,” they write in Diabetes, Obesity and Metabolism. Nevertheless, the 327 study participants in this analysis did retain some benefits of treatment. During 68 weeks of treatment in the STEP 1 trial, people taking semaglutide had lost an average of 17.3% of their bodyweight, whereas those taking placebo lost just 2.0%. During the 52-week extension phase, after stopping randomized treatments, the average weight regain was 11.6 and 1.9 percentage points in the semaglutide and placebo groups, respectively. However, at week 120, bodyweight was still at least 5% below baseline weight in 48.2% of the semaglutide group, compared with 22.6% of the placebo group. The researchers found that people who lost the most weight while taking semaglutide tended to then regain the most after stopping it, although they still retained a larger reduction from baseline than participants who had lost less weight during the treatment period. Wilding and co-authors describe the weight regain after semaglutide withdrawal as “relatively rapid” relative to that after withdrawal of other weight-loss medications, and also after withdrawal of semaglutide 2.4 mg following 20 weeks of treatment in STEP 4. “This may well relate to participants who received semaglutide in STEP 1 having achieved greater weight loss prior to withdrawal than in other trials, and thus having greater potential for regain, driven by physiological and behavioural factors,” they suggest. As well as retaining a degree of weight loss, the trial participants also retained some of the improvement in cardiovascular risk factors observed during the treatment period. Systolic and diastolic blood pressure both returned to baseline values by 52 weeks after treatment withdrawal. But levels of C-reactive protein, high-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and triglycerides were still significantly improved in the semaglutide group relative to placebo group. “Overall, although a net beneficial effect on several cardiometabolic parameters was maintained 1 year after semaglutide withdrawal, greater benefits were seen during the treatment period, supporting the need for continued treatment,” conclude the researchers. medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2022 Springer Healthcare Ltd, part of the Springer Nature Group
Unfortunately, there is no miracle supplement to safely melt away the pounds. “Everyone would like a quick fix. But if it sounds too good to be...
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It's impossible to spot-treat fat and lose it from just one area of your body. Losing weight overall is the only way to lose belly fat in a healthy...
Read More »Eat bland, low-fat foods, like crackers, toast, and rice. Eat foods that contain water, like soups and gelatin. Don't lie down after you eat. Go outside to get some fresh air.
As you decide on how to work toward your weight-management goals, you may have questions. The following are a few frequently asked questions about how to take Saxenda® and the support available if you and your health care provider decide Saxenda® is right for you. If you have immediate questions or experience side effects while on Saxenda®, please reach out to your health care provider. Saxenda® is an injectable prescription medicine that, when used with a reduced-calorie diet and increased physical activity, may help adults with obesity or overweight (excess weight) who also have weight-related medical problems, and children aged 12 to 17 years with a body weight above 132 pounds (60 kg) and obesity, lose weight and keep the weight off. Saxenda® and Victoza® have the same active ingredient, liraglutide, and should not be used together or with other GLP-1 receptor agonist medicines. It is not known if Saxenda® is safe and effective when taken with other prescription, over-the-counter medicines, or herbal weight-loss products. It is not known if Saxenda® is safe and effective in children under 12 years of age. It is not known if Saxenda® is safe and effective in children aged 12 to 17 years with type 2 diabetes. Click here for the full indication.
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