Tropical Weight Loss
Tropical Weight Loss
Photo: Julia Larson
Some antidepressants may contribute to weight loss by decreasing a person's appetite, leading them to consume fewer calories than they burn. In addition, mental health symptoms can affect a person's eating habits and activity levels, and treating the underlying condition may lessen or stop these effects.
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Read More »Antidepressants are effective for treating mental health conditions, but they can affect body weight. Although most antidepressants can cause weight gain, a few may lead to weight loss. Doctors commonly prescribe antidepressants to treat mental health conditions such as depression and anxiety. Serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are second-generation antidepressants. They generally have fewer serious side effects and better tolerability than first-generation antidepressants, such as tricyclic antidepressants (TCAs). The SSRI fluoxetine (Prozac) and the SNRI duloxetine (Cymbalta) can lead to a decrease in appetite and slight weight loss during the first months of treatment. Bupropion (Wellbutrin), which works by blocking norepinephrine and dopamine, may also have this effect. This article explores the link between antidepressants and weight change. It also outlines other side effects and explains how to prevent weight loss. Why do antidepressants affect a person’s weight? Share on Pinterest Paul Taylor/Getty Images Weight gain is a more common side effect of antidepressants than weight loss. A 2019 review of 27 studies found that, on average, individuals experience a 5% increase in weight after starting antidepressant therapy. Various factors could cause a person to gain weight. The possible causes include: Some antidepressants increase appetite, so a person may consume more calories than their body needs. When a person feels depressed, they may become less active and burn fewer calories than they consume. Antidepressants may affect metabolism, causing the body to burn calories more slowly. Some antidepressants may contribute to weight loss by decreasing a person’s appetite, leading them to consume fewer calories than they burn. In addition, mental health symptoms can affect a person’s eating habits and activity levels, and treating the underlying condition may lessen or stop these effects. Learn about how many calories a person needs. Which antidepressants cause weight loss? A few antidepressants cause no weight gain or lead to weight loss. These include: Bupropion: In a 2016 study , participants who did not smoke lost an average of 7.1 pounds (lb) after 2 years of treatment with bupropion compared with those taking fluoxetine. However, those who smoked gained 2.2 lb on average. In a , participants who did not smoke lost an average of 7.1 pounds (lb) after 2 years of treatment with bupropion compared with those taking fluoxetine. However, those who smoked gained 2.2 lb on average. Fluoxetine: A 2022 review found that in adults with overweight or obesity, taking 60 milligrams (mg) of fluoxetine daily can lead to an average weight loss of 2.7 kilograms (kg) — equivalent to almost 6 lb — during the first 6 months of treatment. There is no weight loss effect for people taking low dosages for a longer duration.
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Read More »A 2022 review found that in adults with overweight or obesity, taking 60 milligrams (mg) of fluoxetine daily can lead to an average weight loss of 2.7 kilograms (kg) — equivalent to almost 6 lb — during the first 6 months of treatment. There is no weight loss effect for people taking low dosages for a longer duration. Duloxetine: An older 2006 study found that people taking duloxetine for major depressive disorder lost weight in the short term but gained a small amount during longer-term treatment. It is common for side effects such as weight loss to stabilize as the body adjusts to the medication. Do doctors prescribe antidepressants for weight loss? The Food and Drug Administration (FDA) does not approve antidepressants for weight loss, so doctors do not prescribe them for this use. However, doctors do consider the potential weight change effects of medications when prescribing them. Doctors can prescribe anti-obesity medications to help people with obesity lose weight. The options include: phentermine (Adipex-P)
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